Ccnd3 Gene Detail

Summary

• Symbol
  Ccnd3
• Name
  cyclin D3
• Synonyms
  9230106B05Rik

• Feature Type
  protein coding gene
• IDs
  MGI:88315
  NCBI Gene: 12445
• Alliance
  gene page
• Transcription Start Sites
  71 TSS

Location &
Maps

• Sequence Map
  Chr17:47815976-47910614 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 23.37 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  2673 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88315	protein coding gene	Chr17:47815976-47910616 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023847	protein coding gene	Chr17:48675871-48799286 (+)
A/J	MGP_AJ_G0023807	protein coding gene	Chr17:47451104-47550417 (+)
AKR/J	MGP_AKRJ_G0023776	protein coding gene	Chr17:47835504-47957714 (+)
BALB/cJ	MGP_BALBcJ_G0023809	protein coding gene	Chr17:47364013-47461398 (+)
C3H/HeJ	MGP_C3HHeJ_G0023572	protein coding gene	Chr17:48586071-48692698 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024253	protein coding gene	Chr17:50729718-50841654 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021702	protein coding gene	Chr17:44207872-44304461 (+)
CAST/EiJ	MGP_CASTEiJ_G0023053	protein coding gene	Chr17:48690411-48804659 (+)
CBA/J	MGP_CBAJ_G0023549	protein coding gene	Chr17:52569554-52689532 (+)
DBA/2J	MGP_DBA2J_G0023677	protein coding gene	Chr17:46206446-46307116 (+)
FVB/NJ	MGP_FVBNJ_G0023643	protein coding gene	Chr17:45859375-45965178 (+)
LP/J	MGP_LPJ_G0023757	protein coding gene	Chr17:49354565-49454324 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023671	protein coding gene	Chr17:52058228-52167182 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024298	protein coding gene	Chr17:48200861-48319178 (+)
PWK/PhJ	MGP_PWKPhJ_G0022799	protein coding gene	Chr17:45572434-45678937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022614	protein coding gene	Chr17:45105570-45205066 (+)
WSB/EiJ	MGP_WSBEiJ_G0023119	protein coding gene	Chr17:48784819-48896215 (+)

Homology

• Human Ortholog
  CCND3, cyclin D3

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CCND3, cyclin D3
  
• Links
  HGNC:1585

  NCBI Gene ID: 896

  neXtProt AC: NX_P30281

  UniProt: P30281

  
  
• Chr Location
  6p21.1; chr6:41934933-42050357 (-)  GRCh38

---

• MGI Vertebrate Homology
  Ccnd3 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CCND3
• Protein SuperFamily
  Cyclin_A_B_D_E
• Gene Tree
  Ccnd3
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  17 phenotypes from 4 alleles in 4 genetic backgrounds
  31 phenotypes from multigenic genotypes
  46 phenotype references
  

• All Mutations and Alleles
  542
• Endonuclease-mediated
  4
• Gene trapped
  533
• Targeted
  3
• Transgenic
  2
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  507 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit severe thymus hypoplasia, abnormal thymocyte development, and impaired expansion of immature T lymphocytes.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  38
• GO References
  16

Expression

• Assay Results
  1055
• Tissues
  151
• cDNA Data
  26
• Literature Summary
  116

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA CCND3
  ZFIN ccnd3

Sequences &
Gene Models

• All Sequences
  145
• RefSeq
  12
• UniProt
  14
• CCDS
  CCDS28850.1

• Ensembl
  ENSMUSG00000034165 (Evidence)
• NCBI Gene
  12445

Representative Sequences			Length	Strain/Species
genomic	12445	NCBI Gene Model | MGI Sequence Detail	94639	C57BL/6J
transcript	NM_001081636	RefSeq | MGI Sequence Detail	2131	ZRU/MplStud
polypeptide	P30282	UniProt | EBI | MGI Sequence Detail	292	Not Applicable

Protein
Information

• UniProt
  14 Sequences
• Protein Ontology
  PR:000005123 G1/S-specific cyclin-D3
  (term hierarchy)
• InterPro Domains
  IPR039361 Cyclin
  IPR046965 Cyclin A/B-like
  IPR004367 Cyclin, C-terminal domain
  IPR013763 Cyclin-like domain
  IPR036915 Cyclin-like superfamily
  IPR006671 Cyclin, N-terminal
  IPR048258 Cyclins, cyclin-box

Molecular
Reagents

• All nucleic 42

  cDNA 28

  Primer pair 9

  Other 5

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-1827, MGI:1924959, MGI:2146781, MGI:2146960, MGI:2147051, MGI:2147125

References

• Summaries
  All 228

  Developmental Gene Expression 116

  Gene Ontology 16

  Phenotypes 46
• Earliest
  J:14776 Matsushime H, et al., Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell. 1991 May 17;65(4):701-13
• Latest
  J:352612 Caria CA, et al., Post-GWAS Validation of Target Genes Associated with HbF and HbA(2) Levels. Cells. 2024 Jul 12;13(14)

TSS for Ccnd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144917	Chr17:47815766-47815769 (+)	-208 bp
Tssr144918	Chr17:47815874-47815885 (+)	-96 bp
Tssr144919	Chr17:47815968-47815991 (+)	4 bp
Tssr144920	Chr17:47815998-47816009 (+)	28 bp
Tssr144921	Chr17:47816010-47816030 (+)	44 bp
Tssr144922	Chr17:47816042-47816057 (+)	74 bp
Tssr144923	Chr17:47816083-47816089 (+)	110 bp
Tssr144924	Chr17:47816099-47816107 (+)	127 bp
Tssr144925	Chr17:47816116-47816130 (+)	147 bp
Tssr144926	Chr17:47816136-47816153 (+)	169 bp
Tssr144927	Chr17:47819212-47819231 (+)	3,246 bp
Tssr144928	Chr17:47820118-47820130 (+)	4,148 bp
Tssr144929	Chr17:47820267-47820289 (+)	4,302 bp
Tssr144930	Chr17:47820345-47820365 (+)	4,379 bp
Tssr144931	Chr17:47820373-47820382 (+)	4,402 bp
Tssr5140	Chr17:47820401-47820416 (+)	4,433 bp
Tssr144932	Chr17:47820442-47820459 (+)	4,475 bp
Tssr144933	Chr17:47820488-47820508 (+)	4,522 bp
Tssr144934	Chr17:47820554-47820575 (+)	4,589 bp
Tssr144935	Chr17:47821554-47821563 (+)	5,583 bp
Tssr144936	Chr17:47822804-47822815 (+)	6,834 bp
Tssr144937	Chr17:47822818-47822831 (+)	6,849 bp
Tssr144938	Chr17:47823822-47823835 (+)	7,853 bp
Tssr5141	Chr17:47829807-47829847 (+)	13,851 bp
Tssr5142	Chr17:47832747-47832754 (+)	16,775 bp
Tssr144939	Chr17:47832851-47832861 (+)	16,880 bp
Tssr144943	Chr17:47849361-47849373 (+)	33,391 bp
Tssr144944	Chr17:47849564-47849578 (+)	33,595 bp
Tssr144945	Chr17:47849614-47849620 (+)	33,641 bp
Tssr144946	Chr17:47851202-47851213 (+)	35,232 bp
Tssr144947	Chr17:47851341-47851349 (+)	35,369 bp
Tssr144948	Chr17:47851368-47851384 (+)	35,400 bp
Tssr144949	Chr17:47851412-47851426 (+)	35,443 bp
Tssr144950	Chr17:47851650-47851662 (+)	35,680 bp
Tssr144951	Chr17:47851667-47851680 (+)	35,698 bp
Tssr144952	Chr17:47851683-47851697 (+)	35,714 bp
Tssr144953	Chr17:47853455-47853459 (+)	37,481 bp
Tssr144954	Chr17:47857321-47857333 (+)	41,351 bp
Tssr144955	Chr17:47862085-47862089 (+)	46,111 bp
Tssr144956	Chr17:47868444-47868450 (+)	52,471 bp
Tssr144957	Chr17:47868529-47868545 (+)	52,561 bp
Tssr144958	Chr17:47868625-47868634 (+)	52,654 bp
Tssr144959	Chr17:47868642-47868651 (+)	52,671 bp
Tssr144960	Chr17:47868712-47868751 (+)	52,756 bp
Tssr144961	Chr17:47868753-47868764 (+)	52,783 bp
Tssr144962	Chr17:47868771-47868790 (+)	52,805 bp
Tssr144963	Chr17:47868832-47868851 (+)	52,866 bp
Tssr144964	Chr17:47869330-47869357 (+)	53,368 bp
Tssr5143	Chr17:47891642-47891657 (+)	75,674 bp
Tssr5144	Chr17:47892067-47892069 (+)	76,092 bp
Tssr144965	Chr17:47898192-47898195 (+)	82,218 bp
Tssr144966	Chr17:47898510-47898514 (+)	82,536 bp
Tssr144967	Chr17:47899471-47899475 (+)	83,497 bp
Tssr144968	Chr17:47899793-47899800 (+)	83,821 bp
Tssr144969	Chr17:47901478-47901507 (+)	85,517 bp
Tssr144970	Chr17:47901632-47901636 (+)	85,658 bp
Tssr144971	Chr17:47904369-47904400 (+)	88,409 bp
Tssr144972	Chr17:47904404-47904425 (+)	88,439 bp
Tssr144973	Chr17:47904441-47904470 (+)	88,480 bp
Tssr144974	Chr17:47904477-47904498 (+)	88,512 bp
Tssr144975	Chr17:47904538-47904545 (+)	88,566 bp
Tssr144976	Chr17:47904666-47904677 (+)	88,696 bp
Tssr144977	Chr17:47905506-47905524 (+)	89,539 bp
Tssr144978	Chr17:47905530-47905551 (+)	89,565 bp
Tssr144979	Chr17:47905554-47905570 (+)	89,586 bp
Tssr144980	Chr17:47906986-47906996 (+)	91,015 bp
Tssr144981	Chr17:47906998-47907029 (+)	91,038 bp
Tssr144982	Chr17:47908027-47908043 (+)	92,059 bp
Tssr144983	Chr17:47908438-47908449 (+)	92,468 bp
Tssr144984	Chr17:47909589-47909633 (+)	93,635 bp
Tssr144985	Chr17:47910043-47910054 (+)	94,073 bp