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Cd19 Gene Detail
Summary
  • Symbol
    Cd19
  • Name
    CD19 antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:88319
    NCBI Gene: 12478
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126007622-126014061 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.01 cM, cytoband F3-F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88319
 protein coding gene Chr7:126007620-126016401 (-)
129S1/SvImJ ENSMUSG00200023125
 protein coding gene Chr7:112513015-112520002 (-)
A/J ENSMUSG00195034783
 protein coding gene Chr7:117038224-117056577 (-)
AKR/J ENSMUSG00220021061
 protein coding gene Chr7:110462512-110480765 (-)
BALB/cJ ENSMUSG00180013152
 protein coding gene Chr7:113703184-113721426 (-)
C3H/HeJ ENSMUSG00175014832
 protein coding gene Chr7:114435649-114442671 (-)
C57BL/6NJ ENSMUSG00215008936
 protein coding gene Chr7:113715586-113722608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030444
 protein coding gene Chr7:128424059-128430482 (-)
CAST/EiJ ENSTCUG00005043985
 protein coding gene Chr7:116933373-116950867 (-)
CBA/J ENSMUSG00210022538
 protein coding gene Chr7:114196756-114215082 (-)
DBA/2J ENSMUSG00185036774
 protein coding gene Chr7:118509599-118527924 (-)
FVB/NJ ENSMUSG00205021055
 protein coding gene Chr7:114149179-114167527 (-)
JF1/MsJ ENSUMUG00000018150
 protein coding gene Chr7:123559817-123577184 (-)
LP/J ENSMUSG00230051946
 protein coding gene Chr7:124613005-124631356 (-)
NOD/ShiLtJ ENSMUSG00190017712
 protein coding gene Chr7:114356349-114374570 (-)
NZO/HlLtJ ENSMUSG00225010407
 protein coding gene Chr7:122852205-122870555 (-)
PWK/PhJ ENSLUMG00010040006
 protein coding gene Chr7:112703253-112721581 (-)
SPRET/EiJ ENSMSPG00010010486
 protein coding gene Chr7:113969616-113986780 (-)
WSB/EiJ ENSIUOG00005026432
 protein coding gene Chr7:115056751-115075103 (-)



Homology
more
  • Human Ortholog
    CD19, CD19 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD19, CD19 molecule
  • Synonyms
    B4, CVID3
  • Links
    NCBI Gene ID: 930
    UniProt: P15391

  • Chr Location
    16p11.2; chr16:28931965-28939342 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD19 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 7 genetic backgrounds
    239 phenotypes from multigenic genotypes
    8 images
    907 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal B lymphocyte development, activation and differentiation, altered mast cell activation in a model for acute septic peritonitis, inhibition of bleomycin-induced fibrosis and autoantibody production, and increased susceptibility to EAE.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    3
  • cDNA Data
    43
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030724 Ensembl Gene Model | MGI Sequence Detail 6440 C57BL/6J ±  kb
    transcript ENSMUST00000206325 Ensembl | MGI Sequence Detail 2452 Not Applicable  
    polypeptide ENSMUSP00000145803 Ensembl | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 6
      cDNA 43
      Primer pair 3
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1833, MGI:2142241
    References
    more
    • Summaries
      All 992
      Developmental Gene Expression 9
      Diseases 8
      Gene Ontology 24
      Phenotypes 907
    • Earliest
      J:7105 Nadler LM, et al., B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol. 1983 Jul;131(1):244-50
    • Latest
      J:391215 Nawaz W, et al., Non-canonical NF-kappaB drives a fate switch from germinal center to early effector B cells. iScience. 2026 Aug 21;29(8):116917
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory