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Cd2 Gene Detail
Summary
  • Symbol
    Cd2
  • Name
    CD2 antigen
  • Synonyms
    LFA-2, Ly-37, Ly37
  • Feature Type
    protein coding gene
  • IDs
    MGI:88320
    NCBI Gene: 12481
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:101183224-101195255 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 44.17 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88320
 protein coding gene Chr3:101183215-101195255 (-)
129S1/SvImJ ENSMUSG00200041163
 protein coding gene Chr3:97788675-97800717 (-)
A/J ENSMUSG00195045787
 protein coding gene Chr3:98195163-98207169 (-)
AKR/J ENSMUSG00220039264
 protein coding gene Chr3:96553761-96565798 (-)
BALB/cJ ENSMUSG00180030684
 protein coding gene Chr3:98134771-98146775 (-)
C3H/HeJ ENSMUSG00175024534
 protein coding gene Chr3:97680957-97692956 (-)
C57BL/6NJ ENSMUSG00215012480
 protein coding gene Chr3:98446112-98458151 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025430
 protein coding gene Chr3:95397935-95409934 (-)
CAST/EiJ ENSTCUG00005019065
 protein coding gene Chr3:98403892-98415941 (-)
CBA/J ENSMUSG00210050719
 protein coding gene Chr3:98303130-98315127 (-)
DBA/2J ENSMUSG00185043031
 protein coding gene Chr3:98789294-98801361 (-)
FVB/NJ ENSMUSG00205018111
 protein coding gene Chr3:97365602-97377648 (-)
JF1/MsJ ENSUMUG00000047254
 protein coding gene Chr3:97495413-97507702 (-)
LP/J ENSMUSG00230038919
 protein coding gene Chr3:100717242-100729284 (-)
NOD/ShiLtJ ENSMUSG00190046633
 protein coding gene Chr3:98976831-98988869 (-)
NZO/HlLtJ ENSMUSG00225016028
 protein coding gene Chr3:103168165-103180220 (-)
PWK/PhJ ENSLUMG00010025384
 protein coding gene Chr3:97587636-97599861 (-)
SPRET/EiJ ENSMSPG00010036352
 protein coding gene Chr3:97836362-97848387 (-)
WSB/EiJ ENSIUOG00005030792
 protein coding gene Chr3:98320783-98332734 (-)



Homology
more
  • Human Ortholog
    CD2, CD2 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD2, CD2 molecule
  • Synonyms
    LFA-2, SRBC, T11
  • Links
    NCBI Gene ID: 914
    UniProt: P06729

  • Chr Location
    1p13.1; chr1:116754370-116769229 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    676
  • Tissues
    48
  • cDNA Data
    26
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12481 NCBI Gene Model | MGI Sequence Detail 12032 C57BL/6J ±  kb
transcript NM_013486 RefSeq | MGI Sequence Detail 1144 ZRU/MplStud  
polypeptide P08920 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 3
    cDNA 28
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11978, MGD-MRK-1837
References
more
  • Summaries
    All 91
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 13
    Phenotypes 20
  • Earliest
    J:8607 Williams AF, et al., Similarities in sequences and cellular expression between rat CD2 and CD4 antigens. J Exp Med. 1987 Feb 1;165(2):368-80
  • Latest
    J:350666 Li R, et al., Suppression of adaptive NK cell expansion by macrophage-mediated phagocytosis inhibited by 2B4-CD48. Cell Rep. 2024 Feb 21;43(3):113800
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory