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Cd22 Gene Detail
Summary
  • Symbol
    Cd22
  • Name
    CD22 antigen
  • Synonyms
    Lyb-8, Lyb8
  • Feature Type
    protein coding gene
  • IDs
    MGI:88322
    NCBI Gene: 12483
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30564829-30579767 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.26 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    504 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88322
 protein coding gene Chr7:30564827-30579767 (-)
129S1/SvImJ ENSMUSG00200022534
 protein coding gene Chr7:20333756-20346849 (-)
A/J ENSMUSG00195037746
 protein coding gene Chr7:23009788-23022872 (-)
AKR/J ENSMUSG00220048543
 protein coding gene Chr7:21455800-21468743 (+)
BALB/cJ ENSMUSG00180019311
 protein coding gene Chr7:21069271-21082360 (-)
C3H/HeJ ENSMUSG00175033687
 protein coding gene Chr7:22153859-22166904 (-)
C57BL/6NJ ENSMUSG00215007533
 protein coding gene Chr7:20256048-20269097 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029549
 protein coding gene Chr7:30085074-30099953 (-)
CAST/EiJ ENSTCUG00005038564
 protein coding gene Chr7:22048428-22060746 (-)
CBA/J ENSMUSG00210024914
 protein coding gene Chr7:21316472-21329519 (-)
DBA/2J ENSMUSG00185050535
 protein coding gene Chr7:24399590-24411962 (-)
FVB/NJ ENSMUSG00205010212
 protein coding gene Chr7:21065841-21078896 (-)
JF1/MsJ ENSUMUG00000020110
 protein coding gene Chr7:28841001-28853598 (-)
LP/J ENSMUSG00230053312
 protein coding gene Chr7:29566258-29579202 (-)
NOD/ShiLtJ ENSMUSG00190007943
 protein coding gene Chr7:20734140-20747222 (-)
NZO/HlLtJ ENSMUSG00225024341
 protein coding gene Chr7:28406095-28421427 (-)
PWK/PhJ ENSLUMG00010020986
 protein coding gene Chr7:20768011-20780825 (-)
SPRET/EiJ ENSMSPG00010038187
 protein coding gene Chr7:20136064-20151395 (-)
WSB/EiJ ENSIUOG00005049835
 protein coding gene Chr7:15017641-15030666 (-)



Homology
more
  • Human Ortholog
    CD22, CD22 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD22, CD22 molecule
  • Synonyms
    SIGLEC-2, SIGLEC2
  • Links
    NCBI Gene ID: 933
    UniProt: P20273

  • Chr Location
    19q13.12; chr19:35319261-35347361 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 17 alleles in 15 genetic backgrounds
    7 phenotypes from multigenic genotypes
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    48
  • cDNA Data
    23
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12483 NCBI Gene Model | MGI Sequence Detail 14939 C57BL/6J ±  kb
    transcript NR_102722 RefSeq | MGI Sequence Detail 4169 ZRU/MplStud  
    polypeptide P35329 UniProt | EBI | MGI Sequence Detail 868 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 3
      cDNA 23
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12060, MGD-MRK-12066, MGD-MRK-1839
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 4
      Gene Ontology 14
      Phenotypes 93
    • Earliest
      J:6945 Symington FW, et al., Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics. 1982;16(5):381-91
    • Latest
      J:388135 Yan W, et al., Aurka-Bhlhe41 axis prevents premature aging-like microglial dysfunction and promotes remyelination. Nat Commun. 2026 Mar 27;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory