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Cd40 Gene Detail
Summary
  • Symbol
    Cd40
  • Name
    CD40 antigen
  • Synonyms
    Bp50, Cd40, p50, Tnfrsf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88336
    NCBI Gene: 21939
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164897535-164913574 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.38 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    632 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88336
 protein coding gene Chr2:164897535-164914868 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026886
 protein coding gene Chr2:170580341-170601129 (+)
A/J MGP_AJ_G0026853
 protein coding gene Chr2:163597709-163615011 (+)
AKR/J MGP_AKRJ_G0026824
 protein coding gene Chr2:168480309-168497625 (+)
BALB/cJ MGP_BALBcJ_G0026862
 protein coding gene Chr2:163963664-163980936 (+)
C3H/HeJ MGP_C3HHeJ_G0026604
 protein coding gene Chr2:168829016-168850285 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027309
 protein coding gene Chr2:175521507-175545135 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024680
 protein coding gene Chr2:157004526-157021220 (+)
CAST/EiJ MGP_CASTEiJ_G0026062
 protein coding gene Chr2:169244718-169265734 (+)
CBA/J MGP_CBAJ_G0026581
 protein coding gene Chr2:181892231-181913443 (+)
DBA/2J MGP_DBA2J_G0026719
 protein coding gene Chr2:162763078-162781514 (+)
FVB/NJ MGP_FVBNJ_G0026685
 protein coding gene Chr2:161197415-161215414 (+)
LP/J MGP_LPJ_G0026821
 protein coding gene Chr2:170633725-170654117 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026704
 protein coding gene Chr2:185431860-185451614 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027366
 protein coding gene Chr2:168370542-168389832 (+)
PWK/PhJ MGP_PWKPhJ_G0025799
 protein coding gene Chr2:162365787-162384135 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025600
 protein coding gene Chr2:167282344-167301630 (+)
WSB/EiJ MGP_WSBEiJ_G0026135
 protein coding gene Chr2:169260239-169283775 (+)



Homology
more
  • Human Ortholog
    CD40, CD40 molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD40, CD40 molecule
  • Synonyms
    Bp50, CDW40, p50, TNFRSF5
  • Links
    NCBI Gene ID: 958
    neXtProt AC: NX_P25942
    UniProt: P25942

  • Chr Location
    20q13.12; chr20:46118271-46129863 (+)  GRCh38
Human Diseases
more
  • Diseases
    22 with human CD40 associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 5 alleles in 7 genetic backgrounds
    28 phenotypes from multigenic genotypes
    285 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene may cause impaired immunoglobulin class switching and germinal center formation, reduced susceptibility to type II hypersensitivity reaction, impaired priming of T cells and control of M. tuberculosis infection, and altered response to transplant.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    66
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    57
  • cDNA Data
    25
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21939 NCBI Gene Model | MGI Sequence Detail 16040 C57BL/6J ±  kb
    transcript NR_027852 RefSeq | MGI Sequence Detail 1745 C57BL/6  
    polypeptide P27512 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000001961 tumor necrosis factor receptor superfamily member 5
      (term hierarchy)
    • InterPro Domains
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR052135 Tumor Necrosis Factor Receptor Superfamily Member 5
      IPR020435 Tumour necrosis factor receptor 5
      IPR034021 Tumour necrosis factor receptor 5, N-terminal
    • GlyGen
      P27512 1 site
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 10
      cDNA 25
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1859, MGI:2138913
    References
    more
    • Summaries
      All 504
      Developmental Gene Expression 9
      Gene Ontology 30
      Phenotypes 285
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory