Cd69 MGI Mouse Gene Detail - MGI:88343

Symbol

Cd69
Name

CD69 antigen
Synonyms

5830438K24Rik, AIM, VEA

Feature Type

protein coding gene
IDs

MGI:88343
NCBI Gene: 12515
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr6:129244287-129252332 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 63.21 cM
Mapping Data

11 experiments

SNPs within 2kb

357 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88343	protein coding gene	Chr6:129244287-129252399 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031342	protein coding gene	Chr6:132928738-132936845 (-)
A/J	MGP_AJ_G0031313	protein coding gene	Chr6:127841281-127849394 (-)
AKR/J	MGP_AKRJ_G0031241	protein coding gene	Chr6:131335648-131343761 (-)
BALB/cJ	MGP_BALBcJ_G0031320	protein coding gene	Chr6:127490016-127498141 (-)
C3H/HeJ	MGP_C3HHeJ_G0031044	protein coding gene	Chr6:131521775-131529888 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031779	protein coding gene	Chr6:136419164-136427275 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028925	protein coding gene	Chr6:125346817-125354969 (-)
CAST/EiJ	MGP_CASTEiJ_G0030422	protein coding gene	Chr6:131750019-131758499 (-)
CBA/J	MGP_CBAJ_G0031004	protein coding gene	Chr6:141776925-141785038 (-)
DBA/2J	MGP_DBA2J_G0031161	protein coding gene	Chr6:126793525-126801638 (-)
FVB/NJ	MGP_FVBNJ_G0031111	protein coding gene	Chr6:125674145-125682259 (-)
LP/J	MGP_LPJ_G0031241	protein coding gene	Chr6:133139673-133147849 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031149	protein coding gene	Chr6:145634149-145642259 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031812	protein coding gene	Chr6:131392670-131400915 (-)
PWK/PhJ	MGP_PWKPhJ_G0030140	protein coding gene	Chr6:125075778-125083894 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029969	protein coding gene	Chr6:129417551-129427754 (-)
WSB/EiJ	MGP_WSBEiJ_G0030510	protein coding gene	Chr6:131815268-131823469 (-)

Human Ortholog

CD69, CD69 molecule

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD69, CD69 molecule
Synonyms

AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
Links

HGNC:1694

NCBI Gene ID: 969

neXtProt AC: NX_Q07108

UniProt: Q07108
Chr Location

12p13.31; chr12:9752486-9760901 (-) GRCh38

MGI Vertebrate Homology

Cd69 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CD69
Gene Tree

Cd69

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Phenotype Summary

17 phenotypes from 2 alleles in 3 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

6
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in slightly increased pre-B and immature B cell numbers in the bone marrow, and increased IgG2a and IgM response to T cell-dependent and T cell-independent antigens. Mutant mice were less prone to collagen inducedarthritis.

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All GO Annotations

13
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

4
UniProt

3
CCDS

CCDS20582.1

Ensembl

ENSMUSG00000030156 (Evidence)
NCBI Gene

12515

			Length	Strain/Species	Flank
genomic	12515	NCBI Gene Model \| MGI Sequence Detail	8046	C57BL/6J	± kb
transcript	NM_001033122	RefSeq \| MGI Sequence Detail	1631	ZRU/MplStud
polypeptide	P37217	UniProt \| EBI \| MGI Sequence Detail	199	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001343 CD69 molecule

(term hierarchy)
InterPro Domains

IPR050828 C-type lectin and matrix domain-containing protein

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
GlyGen

P37217 3 sites

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All nucleic 32

Genomic 9

cDNA 22

Primer pair 1

Microarray probesets 3

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MGD-MRK-1869, MGI:1889838, MGI:1923299

Summaries

All 118

Developmental Gene Expression 1

Gene Ontology 23

Phenotypes 35
Earliest

J:9232 Yokoyama WM, et al., Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J Immunol. 1988 Jul 15;141(2):369-76
Latest

J:345669 Nakai S, et al., CD69 Is Indispensable for Development of Functional Local Immune Memory in Murine Contact Hypersensitivity. J Invest Dermatol. 2023 Dec 21;

TSS for Cd69:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63589	Chr6:129252396-129252402 (-)	-67 bp
Tssr63588	Chr6:129252323-129252339 (-)	1 bp
Tssr63587	Chr6:129252051-129252062 (-)	275 bp
Tssr63586	Chr6:129251475-129251485 (-)	852 bp
Tssr63585	Chr6:129251372-129251380 (-)	956 bp
Tssr63584	Chr6:129248773-129248785 (-)	3,553 bp
Tssr63583	Chr6:129248414-129248429 (-)	3,910 bp
Tssr63582	Chr6:129247013-129247023 (-)	5,314 bp
Tssr63581	Chr6:129246627-129246665 (-)	5,686 bp
Tssr63580	Chr6:129246555-129246556 (-)	5,776 bp
Tssr63579	Chr6:129246530-129246542 (-)	5,796 bp
Tssr63578	Chr6:129245257-129245265 (-)	7,071 bp
Tssr63577	Chr6:129245030-129245040 (-)	7,297 bp
Tssr63576	Chr6:129244980-129244996 (-)	7,344 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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