Cdk11b MGI Mouse Gene Detail - MGI:88353 - cyclin dependent kinase 11B

Symbol

Cdk11b
Name

cyclin dependent kinase 11B
Synonyms

Cdc2l1, Cdc2l2, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE proteins

Feature Type

protein coding gene
IDs

MGI:88353
NCBI Gene: 12537
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:155709311-155734395 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.73 cM
Mapping Data

9 experiments

SNPs within 2kb

1015 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88353	protein coding gene	Chr4:155709303-155734395 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029219	protein coding gene	Chr4:159970703-159999328 (+)
A/J	MGP_AJ_G0029184	protein coding gene	Chr4:153246073-153271728 (+)
AKR/J	MGP_AKRJ_G0029132	protein coding gene	Chr4:157410497-157437657 (+)
BALB/cJ	MGP_BALBcJ_G0029200	protein coding gene	Chr4:153718269-153742976 (+)
C3H/HeJ	MGP_C3HHeJ_G0028921	protein coding gene	Chr4:157958240-157983313 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029649	protein coding gene	Chr4:165654825-165681836 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026894	protein coding gene	Chr4:145538622-145561097 (+)
CAST/EiJ	MGP_CASTEiJ_G0028333	protein coding gene	Chr4:155408379-155439065 (+)
CBA/J	MGP_CBAJ_G0028883	protein coding gene	Chr4:170661886-170686587 (+)
DBA/2J	MGP_DBA2J_G0029032	protein coding gene	Chr4:153266385-153291427 (+)
FVB/NJ	MGP_FVBNJ_G0028995	protein coding gene	Chr4:152505869-152531190 (+)
LP/J	MGP_LPJ_G0029122	protein coding gene	Chr4:159890965-159916397 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029022	protein coding gene	Chr4:173468785-173499113 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029681	protein coding gene	Chr4:158034897-158064417 (+)
PWK/PhJ	MGP_PWKPhJ_G0028054	protein coding gene	Chr4:149404268-149431713 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027888	protein coding gene	Chr4:152297304-152323188 (+)
WSB/EiJ	MGP_WSBEiJ_G0028413	protein coding gene	Chr4:158209789-158234775 (+)

Human Ortholog

CDK11A, cyclin dependent kinase 11A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK11A, cyclin dependent kinase 11A
Synonyms

CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE
Links

HGNC:1730

NCBI Gene ID: 728642

neXtProt AC: NX_Q9UQ88

UniProt: Q9UQ88
Chr Location

1p36.33

Human Ortholog

CDK11B, cyclin dependent kinase 11B
Synonyms

CDC2L1, CDK11, CDK11-p110, CDK11-p46, CDK11-p58, CLK-1, p58, p58CDC2L1, p58CLK-1, PITSLREA, PK58
Links

HGNC:1729

NCBI Gene ID: 984

neXtProt AC: NX_P21127

UniProt: P21127
Chr Location

1p36.33; chr1:1635225-1659012 (-) GRCh38

MGI Vertebrate Homology

Cdk11b stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK11A, CDK11B
Gene Tree

Cdk11b

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

1
Gene trapped

17
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null embryos display embryonic lethality from cell cycle arrest.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

128
cDNA Data

102
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDC2L1

Xenbase cdk11b

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All Sequences

85
RefSeq

37
UniProt

5
CCDS

CCDS19033.1, CCDS84837.1

Ensembl

ENSMUSG00000029062 (Evidence)
NCBI Gene

12537

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029062	Ensembl Gene Model \| MGI Sequence Detail	25085	C57BL/6J	± kb
transcript	ENSMUST00000067081	Ensembl \| MGI Sequence Detail	2595	Not Applicable
polypeptide	ENSMUSP00000070527	Ensembl \| MGI Sequence Detail	784	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005196 cyclin-dependent kinase 11B

(term hierarchy)
EC

2.7.11.22
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR045267 Cyclin-dependent kinase 11/PITSLRE, catalytic domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 108

cDNA 106

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-1880, MGI:1098660, MGI:2140185

Summaries

All 53

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 11
Earliest

J:320163 Bunnell BA, et al., Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7467-71
Latest

J:314048 Sala E, et al., CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model. Front Immunol. 2021;12:634797

TSS for Cdk11b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40686	Chr4:155708956-155708971 (+)	-347 bp
Tssr40687	Chr4:155709310-155709386 (+)	37 bp
Tssr40688	Chr4:155709388-155709397 (+)	82 bp
Tssr40689	Chr4:155709424-155709434 (+)	118 bp
Tssr40690	Chr4:155709654-155709673 (+)	353 bp
Tssr1401	Chr4:155709687-155709697 (+)	381 bp
Tssr40691	Chr4:155709979-155710012 (+)	685 bp
Tssr40692	Chr4:155711265-155711282 (+)	1,963 bp
Tssr40693	Chr4:155714978-155714990 (+)	5,673 bp
Tssr1402	Chr4:155715005-155715016 (+)	5,700 bp
Tssr40694	Chr4:155722968-155722980 (+)	13,663 bp
Tssr40695	Chr4:155723000-155723012 (+)	13,695 bp
Tssr40696	Chr4:155723015-155723031 (+)	13,712 bp
Tssr40697	Chr4:155723035-155723048 (+)	13,731 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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