F3 MGI Mouse Gene Detail - MGI:88381 - coagulation factor III

Symbol

F3
Name

coagulation factor III
Synonyms

CD142, Cf-3, Cf3, TF, tissue factor

Feature Type

protein coding gene
IDs

MGI:88381
NCBI Gene: 14066
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:121517186-121528697 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 52.94 cM
Mapping Data

7 experiments

SNPs within 2kb

445 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88381	protein coding gene	Chr3:121517186-121528701 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027833	protein coding gene	Chr3:123928552-123942627 (+)
A/J	MGP_AJ_G0027791	protein coding gene	Chr3:119799037-119810535 (+)
AKR/J	MGP_AKRJ_G0027757	protein coding gene	Chr3:122850352-122861878 (+)
BALB/cJ	MGP_BALBcJ_G0027803	protein coding gene	Chr3:119615718-119627313 (+)
C3H/HeJ	MGP_C3HHeJ_G0027534	protein coding gene	Chr3:123243303-123254812 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028249	protein coding gene	Chr3:128415685-128427291 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025588	protein coding gene	Chr3:115230476-115241190 (+)
CAST/EiJ	MGP_CASTEiJ_G0026990	protein coding gene	Chr3:122620636-122633742 (+)
CBA/J	MGP_CBAJ_G0027509	protein coding gene	Chr3:132763238-132779415 (+)
DBA/2J	MGP_DBA2J_G0027650	protein coding gene	Chr3:118953079-118964338 (+)
FVB/NJ	MGP_FVBNJ_G0027618	protein coding gene	Chr3:116560382-116572367 (+)
LP/J	MGP_LPJ_G0027760	protein coding gene	Chr3:125457515-125469459 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027648	protein coding gene	Chr3:140384556-140396416 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028305	protein coding gene	Chr3:122403365-122414870 (+)
PWK/PhJ	MGP_PWKPhJ_G0026716	protein coding gene	Chr3:118650059-118661677 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026539	protein coding gene	Chr3:120483065-120494088 (+)
WSB/EiJ	MGP_WSBEiJ_G0027070	protein coding gene	Chr3:123125644-123144257 (+)

Human Ortholog

F3, coagulation factor III, tissue factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F3, coagulation factor III, tissue factor
Synonyms

CD142, TF, TFA
Links

HGNC:3541

NCBI Gene ID: 2152

neXtProt AC: NX_P13726

UniProt: P13726
Chr Location

1p21.3; chr1:94529173-94541759 (-) GRCh38

MGI Vertebrate Homology

F3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: F3
Protein SuperFamily

Tissue_factor_3
Gene Tree

F3

Diseases

4 with human F3 associations

				Human Disease	Mouse Models
				B-lymphoblastic leukemia/lymphoma IDs B-lymphoblastic leukemia/lymphoma DOID:0080630 NCI:C8936 UMLS_CUI:C0862030
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670
				disseminated intravascular coagulation IDs disseminated intravascular coagulation DOID:11247 ICD10CM:D65 ICD9CM_2006:286.6 ICD9CM:286.6 MESH:D004211 NCI:C2992 UMLS_CUI:C0012739
				von Willebrand's disease IDs von Willebrand's disease DOID:12531 ICD10CM:D68.0 ICD9CM:286.4 MESH:D014842 NCI:C68677 UMLS_CUI:C0042974

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

63 phenotypes from 7 alleles in 10 genetic backgrounds
18 phenotypes from multigenic genotypes
1 images
86 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

11
Genomic Mutations

2 involving F3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit impaired blood vessel development, retarded growth, and, in most cases, midgestational lethality. On a mixed background, some mutants survive to birth and appear to be normal.

less

All GO Annotations

26
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

988
Tissues

103
cDNA Data

52
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase f3

ZFIN f3a, f3b

less

All Sequences

47
RefSeq

2
UniProt

5
CCDS

CCDS17805.1

Ensembl

ENSMUSG00000028128 (Evidence)
NCBI Gene

14066

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028128	Ensembl Gene Model \| MGI Sequence Detail	11512	C57BL/6J	± kb
transcript	ENSMUST00000029771	Ensembl \| MGI Sequence Detail	1872	Not Applicable
polypeptide	ENSMUSP00000029771	Ensembl \| MGI Sequence Detail	294	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000001940 tissue factor

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR015373 Interferon/interleukin receptor domain

IPR001187 Tissue factor

IPR030472 Tissue factor, conserved site

IPR050650 Type II Cytokine and Tissue Factor Receptors
GlyGen

P20352 4 sites, 3 N-linked glycans (3 sites)

less

All nucleic 59

Genomic 1

cDNA 52

Primer pair 4

Other 2

Microarray probesets 4

less

MGD-MRK-1947, MGD-MRK-1953, MGI:2139567

Summaries

All 164

Developmental Gene Expression 12

Diseases 1

Gene Ontology 5

Phenotypes 86
Earliest

J:9927 Hartzell S, et al., A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol. 1989 Jun;9(6):2567-73
Latest

J:354028 Ballard-Kordeliski A, et al., 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model. Blood. 2024 Sep 5;144(10):1116-1126

TSS for F3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31453	Chr3:121517164-121517183 (+)	-12 bp
Tssr31454	Chr3:121517205-121517210 (+)	22 bp
Tssr31455	Chr3:121517229-121517234 (+)	46 bp
Tssr31456	Chr3:121517250-121517267 (+)	73 bp
Tssr31457	Chr3:121518460-121518475 (+)	1,282 bp
Tssr31458	Chr3:121528269-121528277 (+)	11,087 bp
Tssr31459	Chr3:121528318-121528324 (+)	11,135 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24