Cga MGI Mouse Gene Detail - MGI:88390 - glycoprotein hormones, alpha subunit

Symbol

Cga
Name

glycoprotein hormones, alpha subunit
Synonyms

aGSU, alpha-GSU, alphaGSU, alphaSU, GPHalpha, Tsha

Feature Type

protein coding gene
IDs

MGI:88390
NCBI Gene: 12640
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:34893779-34907370 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 16.86 cM
Mapping Data

24 experiments

SNPs within 2kb

440 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88390	protein coding gene	Chr4:34893779-34907374 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028134	protein coding gene	Chr4:32496694-32511143 (+)
A/J	MGP_AJ_G0028092	protein coding gene	Chr4:31322587-31336884 (+)
AKR/J	MGP_AKRJ_G0028055	protein coding gene	Chr4:32147673-32160746 (+)
BALB/cJ	MGP_BALBcJ_G0028103	protein coding gene	Chr4:31591185-31605573 (+)
C3H/HeJ	MGP_C3HHeJ_G0027832	protein coding gene	Chr4:32459315-32472418 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028545	protein coding gene	Chr4:33734736-33751749 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025886	protein coding gene	Chr4:29417679-29431496 (+)
CAST/EiJ	MGP_CASTEiJ_G0027287	protein coding gene	Chr4:32257327-32274218 (+)
CBA/J	MGP_CBAJ_G0027804	protein coding gene	Chr4:34845846-34861182 (+)
DBA/2J	MGP_DBA2J_G0027948	protein coding gene	Chr4:31294533-31308107 (+)
FVB/NJ	MGP_FVBNJ_G0027914	protein coding gene	Chr4:30713281-30726962 (+)
LP/J	MGP_LPJ_G0028056	protein coding gene	Chr4:32601381-32611132 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027947	protein coding gene	Chr4:37438395-37460116 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028604	protein coding gene	Chr4:32168118-32185343 (+)
PWK/PhJ	MGP_PWKPhJ_G0027006	protein coding gene	Chr4:31324845-31340949 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026835	protein coding gene	Chr4:32030916-32045915 (+)
WSB/EiJ	MGP_WSBEiJ_G0027363	protein coding gene	Chr4:32165755-32181194 (+)

Human Ortholog

CGA, glycoprotein hormones, alpha polypeptide

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CGA, glycoprotein hormones, alpha polypeptide
Synonyms

CG-ALPHA, FSHA, GPA1, GPHa, GPHA1, HCG, LHA, TSHA
Links

HGNC:1885

NCBI Gene ID: 1081

neXtProt AC: NX_P01215

UniProt: P01215
Chr Location

6q14.3; chr6:87085498-87095106 (-) GRCh38

MGI Vertebrate Homology

Cga stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CGA
Gene Tree

Cga

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Phenotype Summary

28 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically and radiation induced

1
Endonuclease-mediated

2
Gene trapped

11
Targeted

3
Genomic Mutations

1 involving Cga
Incidental Mutations

CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mutants exhibit male and female sterility with hypogonadism, dwarfism, hypothyroidism, and both hypertrophy and hyperplasia of pituitary thyrotropes.

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All GO Annotations

28
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

851
Tissues

53
cDNA Data

8
Literature Summary

85

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CGA

Xenbase cga

ZFIN cga

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All Sequences

38
RefSeq

4
UniProt

3
CCDS

CCDS18035.1

Ensembl

ENSMUSG00000028298 (Evidence)
NCBI Gene

12640

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028298	Ensembl Gene Model \| MGI Sequence Detail	13592	C57BL/6J	± kb
transcript	ENSMUST00000029975	Ensembl \| MGI Sequence Detail	687	Not Applicable
polypeptide	ENSMUSP00000029975	Ensembl \| MGI Sequence Detail	120	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005388 glycoprotein hormones alpha chain

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR000476 Glycoprotein hormone alpha chain
GlyGen

P01216 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 28

Genomic 3

cDNA 11

Primer pair 4

Other 10

Microarray probesets 4

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MGD-MRK-15273, MGD-MRK-1964

Summaries

All 166

Developmental Gene Expression 85

Gene Ontology 4

Phenotypes 18
Earliest

J:32632 Vamvakopoulos NC, et al., Synthesis, cloning, and identification of DNA sequences complementary to mRNAs for alpha and beta subunits of thyrotropin. Proc Natl Acad Sci U S A. 1980 Jun;77(6):3149-53
Latest

J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)

TSS for Cga:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36775	Chr4:34893729-34893738 (+)	-45 bp
Tssr36776	Chr4:34893751-34893759 (+)	-24 bp
Tssr36777	Chr4:34893761-34893766 (+)	-15 bp
Tssr36778	Chr4:34893772-34893787 (+)	1 bp
Tssr36779	Chr4:34893794-34893816 (+)	26 bp
Tssr36780	Chr4:34905149-34905158 (+)	11,375 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24