Chgb MGI Mouse Gene Detail - MGI:88395

Symbol

Chgb
Name

chromogranin B
Synonyms

Scg-1, secretogranin I

Feature Type

protein coding gene
IDs

MGI:88395
NCBI Gene: 12653
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:132623562-132636999 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 64.74 cM, cytoband F-G
Mapping Data

12 experiments

SNPs within 2kb

473 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88395	protein coding gene	Chr2:132623198-132636999 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026545	protein coding gene	Chr2:136406852-136422834 (+)
A/J	MGP_AJ_G0026509	protein coding gene	Chr2:130836495-130851274 (+)
AKR/J	MGP_AKRJ_G0026483	protein coding gene	Chr2:134626572-134640332 (+)
BALB/cJ	MGP_BALBcJ_G0026521	protein coding gene	Chr2:131246374-131260528 (+)
C3H/HeJ	MGP_C3HHeJ_G0026264	protein coding gene	Chr2:135059915-135076030 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026966	protein coding gene	Chr2:140552688-140570735 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024343	protein coding gene	Chr2:125566786-125580147 (+)
CAST/EiJ	MGP_CASTEiJ_G0025725	protein coding gene	Chr2:135404535-135420139 (+)
CBA/J	MGP_CBAJ_G0026244	protein coding gene	Chr2:145834320-145850733 (+)
DBA/2J	MGP_DBA2J_G0026378	protein coding gene	Chr2:130225008-130238883 (+)
FVB/NJ	MGP_FVBNJ_G0026342	protein coding gene	Chr2:128858209-128871805 (+)
LP/J	MGP_LPJ_G0026482	protein coding gene	Chr2:136636759-136650392 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026362	protein coding gene	Chr2:149550448-149566674 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027021	protein coding gene	Chr2:134586171-134602225 (+)
PWK/PhJ	MGP_PWKPhJ_G0025461	protein coding gene	Chr2:129838161-129852808 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025263	protein coding gene	Chr2:133748774-133763686 (+)
WSB/EiJ	MGP_WSBEiJ_G0025799	protein coding gene	Chr2:135510196-135524771 (+)

Human Ortholog

CHGB, chromogranin B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHGB, chromogranin B
Synonyms

SCG1
Links

HGNC:1930

NCBI Gene ID: 1114

neXtProt AC: NX_P05060

UniProt: P05060
Chr Location

20p12.3; chr20:5911510-5925353 (+) GRCh38

MGI Vertebrate Homology

Chgb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHGB
Gene Tree

Chgb

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Chgb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced catecholamine secretion from adrenal chromaffin cells.

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All GO Annotations

6
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

102
cDNA Data

63
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CHGB

Xenbase chgb

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All Sequences

41
RefSeq

2
UniProt

6
CCDS

CCDS16777.1

Ensembl

ENSMUSG00000027350 (Evidence)
NCBI Gene

12653

			Length	Strain/Species	Flank
genomic	12653	NCBI Gene Model \| MGI Sequence Detail	13438	C57BL/6J	± kb
transcript	NM_007694	RefSeq \| MGI Sequence Detail	2376	ZRU/MplStud
polypeptide	P16014	UniProt \| EBI \| MGI Sequence Detail	677	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005422 secretogranin-1

(term hierarchy)
InterPro Domains

IPR001819 Chromogranin A/B

IPR001990 Chromogranin A/B/C

IPR018054 Chromogranin, conserved site
GlyGen

P16014 3 sites

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All nucleic 74

Genomic 1

cDNA 66

Primer pair 5

Other 2

Microarray probesets 4

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MGD-MRK-14309, MGD-MRK-1970

Summaries

All 90

Developmental Gene Expression 32

Gene Ontology 5

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:324555 Shue YT, et al., A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nat Commun. 2022 May 16;13(1):2690

TSS for Chgb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20323	Chr2:132622626-132622650 (+)	-924 bp
Tssr20324	Chr2:132623339-132623346 (+)	-219 bp
Tssr20325	Chr2:132623357-132623366 (+)	-200 bp
Tssr20326	Chr2:132623369-132623380 (+)	-187 bp
Tssr20327	Chr2:132623525-132623549 (+)	-25 bp
Tssr20328	Chr2:132623556-132623570 (+)	1 bp
Tssr20329	Chr2:132623582-132623598 (+)	28 bp
Tssr20330	Chr2:132623621-132623636 (+)	67 bp
Tssr20331	Chr2:132627895-132627908 (+)	4,340 bp
Tssr20332	Chr2:132634354-132634389 (+)	10,810 bp
Tssr20333	Chr2:132634448-132634462 (+)	10,893 bp
Tssr20334	Chr2:132635287-132635299 (+)	11,731 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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