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Chrm3 Gene Detail
Summary
  • Symbol
    Chrm3
  • Name
    cholinergic receptor, muscarinic 3, cardiac
  • Synonyms
    Chrm-3, M3R, muscarinic acetylcholine receptor 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88398
    NCBI Gene: 12671
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:9925522-10410883 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 3.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13426 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88398
 protein coding gene Chr13:9925522-10411131 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020226
 protein coding gene Chr13:6528200-7037780 (-)
A/J MGP_AJ_G0020182
 protein coding gene Chr13:6498104-6983666 (-)
AKR/J MGP_AKRJ_G0020157
 protein coding gene Chr13:6600569-7105732 (-)
BALB/cJ MGP_BALBcJ_G0020165
 protein coding gene Chr13:6488317-6984247 (-)
C3H/HeJ MGP_C3HHeJ_G0019969
 protein coding gene Chr13:6719474-7251635 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020612
 protein coding gene Chr13:6891857-7417134 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018219
 protein coding gene Chr13:6406595-6874464 (-)
CAST/EiJ MGP_CASTEiJ_G0019507
 protein coding gene Chr13:6406114-6917241 (-)
CBA/J MGP_CBAJ_G0019936
 protein coding gene Chr13:7060969-7633520 (-)
DBA/2J MGP_DBA2J_G0020053
 protein coding gene Chr13:6324888-6819120 (-)
FVB/NJ MGP_FVBNJ_G0020038
 protein coding gene Chr13:6155595-6642096 (-)
LP/J MGP_LPJ_G0020127
 protein coding gene Chr13:6632563-7127000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020074
 protein coding gene Chr13:7352055-7898768 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020640
 protein coding gene Chr13:6512470-7022921 (-)
PWK/PhJ MGP_PWKPhJ_G0019270
 protein coding gene Chr13:6385269-6872019 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019077
 protein coding gene Chr13:6482315-7015495 (-)
WSB/EiJ MGP_WSBEiJ_G0019567
 protein coding gene Chr13:6444086-6957040 (-)



Homology
more
  • Human Ortholog
    CHRM3, cholinergic receptor muscarinic 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRM3, cholinergic receptor muscarinic 3
  • Synonyms
    EGBRS, HM3, m3AChR, PBS
  • Links
    NCBI Gene ID: 1131
    neXtProt AC: NX_P20309
    UniProt: P20309

  • Chr Location
    1q43; chr1:239386565-239915452 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chrm3 mouse models; 4 with human CHRM3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 7 alleles in 11 genetic backgrounds
    10 phenotypes from multigenic genotypes
    2 images
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show reduced body weight and gonadal fat pad weight, decreased food intake, and low serum levels of leptin, triglycerides and insulin. Dilated pupils, hydronephrosis, and impaired contractility of smooth muscle are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    156
  • cDNA Data
    12
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046159 Ensembl Gene Model | MGI Sequence Detail 485362 C57BL/6J ±  kb
    transcript ENSMUST00000063093 Ensembl | MGI Sequence Detail 1770 Not Applicable  
    polypeptide ENSMUSP00000055579 Ensembl | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 13
      Primer pair 3
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1976, MGD-MRK-1980
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 11
      Phenotypes 94
    • Earliest
      J:9472 Shapiro RA, et al., Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene [published erratum appears in J Biol Chem 1989 Apr 15;264(11):6596]. J Biol Chem. 1988 Dec 5;263(34):18397-403
    • Latest
      J:339160 Zheng F, et al., Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice. Cells. 2023 Jul 19;12(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory