Col15a1 MGI Mouse Gene Detail - MGI:88449 - collagen, type XV, alpha 1

Symbol

Col15a1
Name

collagen, type XV, alpha 1

Feature Type

protein coding gene
IDs

MGI:88449
NCBI Gene: 12819
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr4:47208161-47313167 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 26.01 cM, cytoband B1-B3
Mapping Data

4 experiments

SNPs within 2kb

2843 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88449	protein coding gene	Chr4:47207744-47313167 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028266	protein coding gene	Chr4:45576935-45687889 (+)
A/J	MGP_AJ_G0028225	protein coding gene	Chr4:43863950-43968979 (+)
AKR/J	MGP_AKRJ_G0028175	protein coding gene	Chr4:44974843-45079859 (+)
BALB/cJ	MGP_BALBcJ_G0028245	protein coding gene	Chr4:43986364-44091250 (+)
C3H/HeJ	MGP_C3HHeJ_G0027966	protein coding gene	Chr4:45561548-45676434 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028686	protein coding gene	Chr4:47252506-47367006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025995	protein coding gene	Chr4:41245484-41349891 (+)
CAST/EiJ	MGP_CASTEiJ_G0027405	protein coding gene	Chr4:45152203-45256503 (+)
CBA/J	MGP_CBAJ_G0027932	protein coding gene	Chr4:48755151-48873287 (+)
DBA/2J	MGP_DBA2J_G0028082	protein coding gene	Chr4:43770411-43875458 (+)
FVB/NJ	MGP_FVBNJ_G0028049	protein coding gene	Chr4:43035456-43141209 (+)
LP/J	MGP_LPJ_G0028181	protein coding gene	Chr4:45632645-45743081 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028073	protein coding gene	Chr4:51793207-51914638 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028721	protein coding gene	Chr4:45194774-45306231 (+)
PWK/PhJ	MGP_PWKPhJ_G0027130	protein coding gene	Chr4:43878262-43985819 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026958	protein coding gene	Chr4:44702626-44808901 (+)
WSB/EiJ	MGP_WSBEiJ_G0027483	protein coding gene	Chr4:45117572-45227196 (+)

Human Ortholog

COL15A1, collagen type XV alpha 1 chain

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COL15A1, collagen type XV alpha 1 chain
Links

HGNC:2192

NCBI Gene ID: 1306

neXtProt AC: NX_P39059

UniProt: P39059
Chr Location

9q22.33; chr9:98943179-99070787 (+) GRCh38

MGI Vertebrate Homology

Col15a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: COL15A1
Gene Tree

Col15a1

less

Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
2 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

71 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in abnormal muscle cells of variable size (including atrophic and split muscle cells), susceptibility to exercise-induced muscle injury, and abnormalities in heart and skeletal muscle capillary endothelium.

less

All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1020
Tissues

117
cDNA Data

97
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase col15a1

ZFIN col15a1a, col15a1b

less

All Sequences

52
RefSeq

3
UniProt

6
CCDS

CCDS18159.1

Ensembl

ENSMUSG00000028339 (Evidence)
NCBI Gene

12819

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028339	Ensembl Gene Model \| MGI Sequence Detail	105007	C57BL/6J	± kb
transcript	ENSMUST00000102917	Ensembl \| MGI Sequence Detail	5172	Not Applicable
polypeptide	ENSMUSP00000099981	Ensembl \| MGI Sequence Detail	1367	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000005699 collagen alpha-1(XV) chain

(term hierarchy)
PDB

1DY2
InterPro Domains

IPR010515 Collagenase NC10/endostatin

IPR050149 Collagen superfamily

IPR008160 Collagen triple helix repeat

IPR045463 Collagen type XV/XVIII, trimerization domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR016187 C-type lectin fold

IPR016186 C-type lectin-like/link domain superfamily

IPR001791 Laminin G domain

IPR048287 Thrombospondin-like, N-terminal domain
GlyGen

O35206 13 sites, 1 N-linked glycan (1 site)

less

All nucleic 102

Genomic 2

cDNA 98

Primer pair 2

Microarray probesets 3

less

MGD-MRK-2056

Summaries

All 62

Developmental Gene Expression 19

Gene Ontology 7

Phenotypes 14
Earliest

J:15411 Abe N, et al., Identification of a novel collagen chain represented by extensive interruptions in the triple-helical region. Biochem Biophys Res Commun. 1993 Oct 29;196(2):576-82
Latest

J:343095 Honeycutt SE, et al., Netrin 1 directs vascular patterning and maturity in the developing kidney. Development. 2023 Nov 15;150(22)

TSS for Col15a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37149	Chr4:47207581-47207595 (+)	-573 bp
Tssr37150	Chr4:47208005-47208088 (+)	-114 bp
Tssr37151	Chr4:47208237-47208252 (+)	84 bp
Tssr37152	Chr4:47208265-47208276 (+)	110 bp
Tssr37153	Chr4:47208280-47208292 (+)	125 bp
Tssr37154	Chr4:47208298-47208316 (+)	146 bp
Tssr37155	Chr4:47242395-47242404 (+)	34,239 bp
Tssr37156	Chr4:47259701-47259717 (+)	51,548 bp
Tssr1169	Chr4:47284270-47284316 (+)	76,132 bp
Tssr37157	Chr4:47285960-47285966 (+)	77,802 bp
Tssr37158	Chr4:47287828-47287835 (+)	79,671 bp
Tssr37159	Chr4:47288062-47288076 (+)	79,908 bp
Tssr37160	Chr4:47288434-47288455 (+)	80,284 bp
Tssr37161	Chr4:47306053-47306081 (+)	97,906 bp
Tssr37162	Chr4:47312195-47312226 (+)	104,050 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24