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Comp Gene Detail
Summary
  • Symbol
    Comp
  • Name
    cartilage oligomeric matrix protein
  • Synonyms
    thrombospondin-5, TSP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:88469
    NCBI Gene: 12845
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70826208-70834716 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88469
 protein coding gene Chr8:70826186-70834721 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033703
 protein coding gene Chr8:70639244-70647842 (+)
A/J MGP_AJ_G0033686
 protein coding gene Chr8:67768207-67776787 (+)
AKR/J MGP_AKRJ_G0033611
 protein coding gene Chr8:69695826-69704423 (+)
BALB/cJ MGP_BALBcJ_G0033682
 protein coding gene Chr8:67988948-67997576 (+)
C3H/HeJ MGP_C3HHeJ_G0033392
 protein coding gene Chr8:70341305-70349976 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034199
 protein coding gene Chr8:73309684-73318191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031143
 protein coding gene Chr8:62585120-62593542 (+)
CAST/EiJ MGP_CASTEiJ_G0032717
 protein coding gene Chr8:69827054-69835592 (+)
CBA/J MGP_CBAJ_G0033370
 protein coding gene Chr8:75939556-75948154 (+)
DBA/2J MGP_DBA2J_G0033524
 protein coding gene Chr8:67489054-67497682 (+)
FVB/NJ MGP_FVBNJ_G0033465
 protein coding gene Chr8:66599698-66608315 (+)
LP/J MGP_LPJ_G0033611
 protein coding gene Chr8:70666683-70675281 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033508
 protein coding gene Chr8:78608332-78616810 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034217
 protein coding gene Chr8:69882700-69891298 (+)
PWK/PhJ MGP_PWKPhJ_G0032425
 protein coding gene Chr8:66785078-66793694 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032261
 protein coding gene Chr8:68851086-68859642 (+)
WSB/EiJ MGP_WSBEiJ_G0032832
 protein coding gene Chr8:70240550-70249195 (+)



Homology
more
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMP, cartilage oligomeric matrix protein
  • Synonyms
    CTS2, EDM1, EPD1, MED, PSACH, THBS5, TSP-5, TSP5
  • Links
    NCBI Gene ID: 1311
    neXtProt AC: NX_P49747
    UniProt: P49747

  • Chr Location
    19p13.11; chr19:18782773-18791305 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Comp mouse models; 4 with human COMP associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are indistinguishable from controls. Mice homozygous for a knockin allele with two point mutations exhibit short limb dwarfism, osteoarthritis, abnormal chondrocytes, mild myopathy, and abnormal tendon morphology and stiffness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    63
  • cDNA Data
    21
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031849 Ensembl Gene Model | MGI Sequence Detail 8509 C57BL/6J ±  kb
    transcript ENSMUST00000003659 Ensembl | MGI Sequence Detail 2416 Not Applicable  
    polypeptide ENSMUSP00000003659 Ensembl | MGI Sequence Detail 755 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000000085 cartilage oligomeric matrix protein
      (term hierarchy)
    • PDB
      1MZ9, 3V2N, 3V2P, 3V2Q, 3V2R
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR039081 Thrombospondin-5, coiled coil domain
      IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
      IPR046970 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily
      IPR008859 Thrombospondin, C-terminal
      IPR003367 Thrombospondin, type 3-like repeat
      IPR017897 Thrombospondin, type 3 repeat
      IPR028974 TSP type-3 repeat
    • GlyGen
      Q9R0G6 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 21
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2091
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 30
      Diseases 4
      Gene Ontology 22
      Phenotypes 29
    • Earliest
      J:22324 Newton G, et al., Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994 Dec;24(3):435-9
    • Latest
      J:340421 Ruscitto A, et al., Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell Stem Cell. 2023 Sep 7;30(9):1179-1198.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory