Cr2 MGI Mouse Gene Detail - MGI:88489

Symbol

Cr2
Name

complement receptor 2
Synonyms

C3DR, CD21, CD35, Cr-1, Cr1, Cr-2

Feature Type

protein coding gene
IDs

MGI:88489
NCBI Gene: 12902
Alliance

genome feature page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr1:194819119-194859024 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 98.44 cM
Mapping Data

12 experiments

SNPs within 2kb

535 from dbSNP Build 142
Strain Annotations

19
PCR

1
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88489	protein coding gene	Chr1:194819119-194859096 (-)
129S1/SvImJ	ENSMUSG00200004028	protein coding gene	Chr1:192619313-192656349 (-)
A/J	ENSMUSG00195008473	protein coding gene	Chr1:192197964-192235004 (-)
AKR/J	ENSMUSG00220004218	protein coding gene	Chr1:191455306-191492330 (-)
BALB/cJ	ENSMUSG00180017918	protein coding gene	Chr1:192264837-192301868 (-)
C3H/HeJ	ENSMUSG00175021535	protein coding gene	Chr1:192499999-192537039 (-)
C57BL/6NJ	ENSMUSG00215011307	protein coding gene	Chr1:191658360-191695389 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015076	protein coding gene	Chr1:185402204-185440865 (-)
CAST/EiJ	ENSTCUG00005002036	protein coding gene	Chr1:190224571-190261507 (-)
CBA/J	ENSMUSG00210003475	protein coding gene	Chr1:192130803-192167841 (-)
DBA/2J	ENSMUSG00185010058	protein coding gene	Chr1:196731627-196768664 (-)
FVB/NJ	ENSMUSG00205004352	protein coding gene	Chr1:191094319-191131362 (-)
JF1/MsJ	ENSUMUG00000008049	protein coding gene	Chr1:195699031-195736301 (-)
LP/J	ENSMUSG00230002160	protein coding gene	Chr1:196233800-196270840 (-)
NOD/ShiLtJ	ENSMUSG00190028701	protein coding gene	Chr1:192093458-192130421 (-)
NZO/HlLtJ	ENSMUSG00225016060	protein coding gene	Chr1:199991728-200029638 (-)
PWK/PhJ	ENSLUMG00010006414	protein coding gene	Chr1:190949537-190986591 (-)
SPRET/EiJ	ENSMSPG00010000040	protein coding gene	Chr1:194469144-194560281 (-)
WSB/EiJ	ENSIUOG00005004136	protein coding gene	Chr1:191423301-191460211 (-)

Human Ortholog

CR2, complement C3d receptor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CR2, complement C3d receptor 2
Synonyms

C3DR, CD21, CR, CVID7, SLEB9
Links

HGNC:2336

NCBI Gene ID: 1380

UniProt: P20023
Chr Location

1q32.2; chr1:207453024-207489895 (+) GRCh38

MGI Vertebrate Homology

Cr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CR2
Gene Tree

Cr2

Diseases

3 with human CR2 associations

				Human Disease	Mouse Models
				common variable immunodeficiency 7 IDs common variable immunodeficiency 7 DOID:0081150 OMIM:614699
				nasopharynx carcinoma IDs nasopharynx carcinoma DOID:9261 DOID:8813 DOID:8814 DOID:9057 DOID:9144 DOID:9197 DOID:9229 ICD10CM:C11 ICD10CM:C11.0 ICD10CM:C11.1 ICD10CM:C11.2 ICD10CM:C11.3 ICD9CM:147 ICD9CM:147.0 ICD9CM:147.1 ICD9CM:147.2 ICD9CM:147.3 ICD9CM:147.9 MESH:D009303 NCI:C194054 NCI:C194055 NCI:C194056 NCI:C194057 NCI:C9321 OMIM:161550 OMIM:607107 ORDO:150 UMLS_CUI:C0153392 UMLS_CUI:C0153393 UMLS_CUI:C0153394 UMLS_CUI:C0153395 UMLS_CUI:C0153396
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

37 phenotypes from 7 alleles in 10 genetic backgrounds
2 phenotypes from multigenic genotypes
99 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (ENU)

1
Endonuclease-mediated

5
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

81 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation.

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All GO Annotations

37
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

639
Tissues

35
cDNA Data

36
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

77
RefSeq

13
UniProt

11
CCDS

CCDS15642.1, CCDS87949.1

Ensembl

ENSMUSG00000026616 (Evidence)
NCBI Gene

12902

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026616	Ensembl Gene Model \| MGI Sequence Detail	39906	C57BL/6J	± kb
transcript	ENSMUST00000210219	Ensembl \| MGI Sequence Detail	4227	Not Applicable
polypeptide	ENSMUSP00000147804	Ensembl \| MGI Sequence Detail	1408	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000001338 complement receptor type 2

(term hierarchy)
InterPro Domains

IPR051277 SEZ6/CSMD/C4BPB Neuronal & Immune Regulators

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

P19070 17 sites

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All nucleic 52

Genomic 12

cDNA 37

Primer pair 2

Other 1

Antibodies 1

Microarray probesets 4

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MGD-MRK-2122, MGD-MRK-2123, MGD-MRK-2124, MGD-MRK-2125

Summaries

All 194

Developmental Gene Expression 7

Gene Ontology 15

Phenotypes 99
Earliest

J:7312 Bubbers JE, Identification and linkage analyses of a gene, Rcs-1, suppressing spontaneous SJL/J lymphoma expression. J Natl Cancer Inst. 1984 Feb;72(2):441-6
Latest

J:370750 Rodrigues KA, et al., Vaccines combining slow release and follicle targeting of antigens increase germinal center B cell diversity and clonal expansion. Sci Transl Med. 2025 Jun 18;17(803):eadw7499

TSS for Cr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15877	Chr1:194859080-194859091 (-)	-62 bp
Tssr15876	Chr1:194859015-194859033 (-)	0 bp
Tssr385	Chr1:194858995-194859002 (-)	25 bp
Tssr384	Chr1:194858967-194858990 (-)	45 bp
Tssr15875	Chr1:194858945-194858954 (-)	74 bp

Cr2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Sle1c	Chr1, 94.73 cM	Chr1:188594514-189303617	J:73128	The NZM2410 interval contains the Sle1 QTLs and originated from an (NZB x NZW) cross. In order to construct congenic strains of mice which contain selected Sle loci, NZM2410 were backcrossed to C57BL/6J mice six successive times, screening progeny withPCR or SSR markers for specific genomic intervals. One such locus Sle1c resided in an interval of mouse Chromosome 1 that contained Cr2 which is a possible candidate for Sle1c. There were at least 16 nucleotide sequence differences between NZW and C57BL/6J at the Cr2 locus. The authors provided evidence suggesting that Cr2 is the disease susceptibility gene corresponding to the Sle1c QTL.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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