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Creb1 Gene Detail
Summary
  • Symbol
    Creb1
  • Name
    cAMP responsive element binding protein 1
  • Synonyms
    2310001E10Rik, 3526402H21Rik, Creb, Creb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88494
    NCBI Gene: 12912
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:64571963-64643707 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.74 cM, cytoband C1/C5
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1609 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88494
 protein coding gene Chr1:64571804-64643707 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016095
 protein coding gene Chr1:64703769-64781818 (+)
A/J MGP_AJ_G0016078
 protein coding gene Chr1:62430463-62496540 (+)
AKR/J MGP_AKRJ_G0016035
 protein coding gene Chr1:64171263-64244114 (+)
BALB/cJ MGP_BALBcJ_G0016033
 protein coding gene Chr1:62524156-62594463 (+)
C3H/HeJ MGP_C3HHeJ_G0015865
 protein coding gene Chr1:64449435-64524146 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016486
 protein coding gene Chr1:67211120-67288891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014207
 protein coding gene Chr1:58483238-58555302 (+)
CAST/EiJ MGP_CASTEiJ_G0015448
 protein coding gene Chr1:63716864-63789034 (+)
CBA/J MGP_CBAJ_G0015837
 protein coding gene Chr1:69393442-69475944 (+)
DBA/2J MGP_DBA2J_G0015938
 protein coding gene Chr1:61835539-61901983 (+)
FVB/NJ MGP_FVBNJ_G0015941
 protein coding gene Chr1:61112217-61183047 (+)
LP/J MGP_LPJ_G0016010
 protein coding gene Chr1:65610054-65684764 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015961
 protein coding gene Chr1:72262487-72343335 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016533
 protein coding gene Chr1:64159132-64230869 (+)
PWK/PhJ MGP_PWKPhJ_G0015235
 protein coding gene Chr1:61213727-61288386 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015014
 protein coding gene Chr1:63647297-63720430 (+)
WSB/EiJ MGP_WSBEiJ_G0015510
 protein coding gene Chr1:63865779-63938094 (+)



Homology
more
  • Human Ortholog
    CREB1, cAMP responsive element binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREB1, cAMP responsive element binding protein 1
  • Synonyms
    CREB, CREB-1
  • Links
    NCBI Gene ID: 1385
    neXtProt AC: NX_P16220
    UniProt: P16220

  • Chr Location
    2q33.3; chr2:207529737-207605988 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CREB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 7 alleles in 6 genetic backgrounds
    30 phenotypes from multigenic genotypes
    3 images
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for alleles lacking some or all isotypes exhibit a range of defects involving circadian rhythms, axonal growth, sensory neuron survival, long-term memory, fear conditioning, body size, respiration, and neonatal viability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    117
  • GO References
    40
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    74
  • cDNA Data
    168
  • Literature Summary
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12912 NCBI Gene Model | MGI Sequence Detail 71745 C57BL/6J ±  kb
    transcript NM_009952 RefSeq | MGI Sequence Detail 8431 ZRU/MplStud  
    polypeptide Q01147 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000005854 cyclic AMP-responsive element-binding protein 1
      (term hierarchy)
    • PDB
      1DH3
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR001630 cAMP response element binding (CREB) protein
      IPR003102 Cyclic AMP-responsive element-binding protein 1-like, pKID
    • GlyGen
      Q01147 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 191
      Genomic 13
      cDNA 173
      Primer pair 4
      Other 1

      Microarray probesets 14
    Other
    Accession IDs
    less
    MGD-MRK-2134, MGD-MRK-2135, MGD-MRK-2136, MGI:1913601, MGI:1913933, MGI:2138519
    References
    more
    • Summaries
      All 434
      Developmental Gene Expression 77
      Gene Ontology 40
      Phenotypes 119
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353354 Desiderio S, et al., Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2. Elife. 2024 Feb 22;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory