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Crem Gene Detail
Summary
  • Symbol
    Crem
  • Name
    cAMP responsive element modulator
  • Synonyms
    ICER
  • Feature Type
    protein coding gene
  • IDs
    MGI:88495
    NCBI Gene: 12916
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:3266048-3337748 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 2.14 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1233 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88495
 protein coding gene Chr18:3263181-3337748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024118
 protein coding gene Chr18:46040-124750 (-)
A/J MGP_AJ_G0024080
 protein coding gene Chr18:105263-178821 (-)
AKR/J MGP_AKRJ_G0024048
 protein coding gene Chr18:107028-180084 (-)
BALB/cJ MGP_BALBcJ_G0024080
 protein coding gene Chr18:137994-217073 (-)
C3H/HeJ MGP_C3HHeJ_G0023845
 protein coding gene Chr18:61367-145540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024525
 protein coding gene Chr18:125069-221551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021964
 protein coding gene Chr18:54526-120517 (-)
CAST/EiJ MGP_CASTEiJ_G0023324
 protein coding gene Chr18:78533-150762 (-)
CBA/J MGP_CBAJ_G0023819
 protein coding gene Chr18:84875-160488 (-)
DBA/2J MGP_DBA2J_G0023947
 protein coding gene Chr18:59870-133049 (-)
FVB/NJ MGP_FVBNJ_G0023913
 protein coding gene Chr18:63598-141815 (-)
LP/J MGP_LPJ_G0024031
 protein coding gene Chr18:87308-171112 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023941
 protein coding gene Chr18:69167-145014 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024570
 protein coding gene Chr18:63387-140924 (-)
PWK/PhJ MGP_PWKPhJ_G0023069
 protein coding gene Chr18:108689-182527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022880
 protein coding gene Chr18:323403-402498 (-)
WSB/EiJ MGP_WSBEiJ_G0023390
 protein coding gene Chr18:64697-139198 (-)



Homology
more
  • Human Ortholog
    CREM, cAMP responsive element modulator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CREM, cAMP responsive element modulator
  • Synonyms
    CREM-2, hCREM-2, ICER
  • Links
    NCBI Gene ID: 1390
    neXtProt AC: NX_Q03060
    UniProt: Q03060

  • Chr Location
    10p11.21; chr10:35126791-35212958 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit reduced regenerative capacity after partial hepatectomy and reduced cardiac function. Males are sterile due to a block in spermiogenesis associated with a lack of postmeiotic gene expression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    902
  • Tissues
    155
  • cDNA Data
    19
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063889 Ensembl Gene Model | MGI Sequence Detail 71701 C57BL/6J ±  kb
    transcript ENSMUST00000150235 Ensembl | MGI Sequence Detail 2662 Not Applicable  
    polypeptide ENSMUSP00000121233 Ensembl | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      32 Sequences
    • Protein Ontology
      PR:000005866 cAMP-responsive element modulator
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR001630 cAMP response element binding (CREB) protein
      IPR003102 Cyclic AMP-responsive element-binding protein 1-like, pKID
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 21
      Primer pair 7

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-2137
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 29
      Gene Ontology 14
      Phenotypes 54
    • Earliest
      J:18605 Foulkes NS, et al., CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell. 1991 Feb 22;64(4):739-49
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory