cri Gene Detail

Summary

• Symbol
  cri
• Name
  cribriform degeneration

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:88500
  NCBI Gene: 12924
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  25 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygotes for a spontaneous mutation exhibit normocytic anemia, electrolyte imbalance, ataxia, muscle weakness, and vacuolar degeneration of the brainstem, spinal cord, and retinal inner nuclear layer. Condition is lethal.

Sequences &
Gene Models

• NCBI Gene
  12924

Other
Accession IDs

MGD-MRK-2143

References

• Summaries
  All 9

  Phenotypes 7
• Earliest
  J:5277 Green MC, et al., Cribriform degeneration (cri): a new recessive neurological mutation in the mouse. Science. 1972 May 19;176(36):800-3
• Latest
  J:14607 Catanzaro OL, et al., Trypsine-like esteroproteases, kinin and kininases in submandibular gland, colon and pulmonary lavage fluid of mouse model for human cystic fibrosis (CF). Adv Exp Med Biol. 1989;247B:639-42