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Cr1l Gene Detail
Summary
  • Symbol
    Cr1l
  • Name
    complement C3b/C4b receptor 1 like
  • Synonyms
    Crry, mCRY
  • Feature Type
    protein coding gene
  • IDs
    MGI:88513
    NCBI Gene: 12946
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:194781019-194813878 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 98.43 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    478 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88513
 protein coding gene Chr1:194779690-194813894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016968
 protein coding gene Chr1:202273220-202314745 (-)
A/J MGP_AJ_G0016947
 protein coding gene Chr1:193968833-194003986 (-)
AKR/J MGP_AKRJ_G0016912
 protein coding gene Chr1:199709074-199745514 (-)
BALB/cJ MGP_BALBcJ_G0016905
 protein coding gene Chr1:194669533-194703388 (-)
C3H/HeJ MGP_C3HHeJ_G0016729
 protein coding gene Chr1:200601373-200637007 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017368
 protein coding gene Chr1:208650604-208685623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015075
 protein coding gene Chr1:185362155-185396325 (-)
CAST/EiJ MGP_CASTEiJ_G0016312
 protein coding gene Chr1:200157944-200196476 (-)
CBA/J MGP_CBAJ_G0016703
 protein coding gene Chr1:216346846-216380772 (-)
DBA/2J MGP_DBA2J_G0016809
 protein coding gene Chr1:192690161-192723752 (-)
FVB/NJ MGP_FVBNJ_G0016805
 protein coding gene Chr1:190782506-190816850 (-)
LP/J MGP_LPJ_G0016884
 protein coding gene Chr1:203406640-203444830 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016837
 protein coding gene Chr1:222998746-223042221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017405
 protein coding gene Chr1:199552969-199588388 (-)
PWK/PhJ MGP_PWKPhJ_G0016099
 protein coding gene Chr1:191998156-192032759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015875
 protein coding gene Chr1:198599907-198637785 (-)
WSB/EiJ MGP_WSBEiJ_G0016374
 protein coding gene Chr1:199836621-199873402 (-)



Homology
more
  • Human Ortholog
    CR1, complement C3b/C4b receptor 1 (Knops blood group)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CR1, complement C3b/C4b receptor 1 (Knops blood group)
  • Synonyms
    C3BR, C4BR, CD35, KN
  • Links
    NCBI Gene ID: 1378
    neXtProt AC: NX_P17927
    UniProt: P17927

  • Chr Location
    1q32.2; chr1:207496147-207641765 (+)  GRCh38
  • Human Ortholog
    CR1L, complement C3b/C4b receptor 1 like
  • Links
    NCBI Gene ID: 1379
    neXtProt AC: NX_Q2VPA4
    UniProt: Q2VPA4

  • Chr Location
    1q32.2; chr1:207645113-207738416 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die by E16.5 with abnormal C3 deposition. Mice homozygous for a null allele activated in single positive thymocytes exhibit T cell lymphopenia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    115
  • cDNA Data
    116
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12946 NCBI Gene Model | MGI Sequence Detail 32860 C57BL/6J ±  kb
    transcript NM_001355061 RefSeq | MGI Sequence Detail 1696 ZRU/MplStud  
    polypeptide Q64735 UniProt | EBI | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      Genomic 10
      cDNA 124
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12142, MGD-MRK-2158
    References
    more
    • Summaries
      All 98
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 44
    • Earliest
      J:8686 Aegerter-Shaw M, et al., Expansion of the complement receptor gene family. Identification in the mouse of two new genes related to the CR1 and CR2 gene family. J Immunol. 1987 May 15;138(10):3488-94
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory