Crygf MGI Mouse Gene Detail - MGI:88526

Symbol

Crygf
Name

crystallin, gamma F
Synonyms

3110001K11Rik, Cryg-2, DGcry-2, Len-2

Feature Type

protein coding gene
IDs

MGI:88526
NCBI Gene: 12969
Member of

Cryg cluster
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:65965679-65967466 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 33.31 cM, cytoband C3
Mapping Data

14 experiments

SNPs within 2kb

76 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88526	protein coding gene	Chr1:65965679-65967470 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016111	protein coding gene	Chr1:66195696-66198536 (+)
A/J	MGP_AJ_G0016094	protein coding gene	Chr1:63851344-63853130 (+)
AKR/J	MGP_AKRJ_G0016051	protein coding gene	Chr1:65640840-65642649 (+)
BALB/cJ	MGP_BALBcJ_G0016049	protein coding gene	Chr1:63908117-63909915 (+)
C3H/HeJ	MGP_C3HHeJ_G0015880	protein coding gene	Chr1:65916489-65918303 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016502	protein coding gene	Chr1:68722124-68723990 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014223	protein coding gene	Chr1:59838886-59840677 (+)
CAST/EiJ	MGP_CASTEiJ_G0015464	protein coding gene	Chr1:65169127-65173604 (+)
CBA/J	MGP_CBAJ_G0015853	protein coding gene	Chr1:70964443-70968477 (+)
DBA/2J	MGP_DBA2J_G0015954	protein coding gene	Chr1:63231689-63233485 (+)
FVB/NJ	MGP_FVBNJ_G0015957	protein coding gene	Chr1:62505421-62507217 (+)
LP/J	MGP_LPJ_G0016026	protein coding gene	Chr1:67110668-67112454 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015977	protein coding gene	Chr1:73911544-73913762 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016549	protein coding gene	Chr1:65606393-65608180 (+)
PWK/PhJ	MGP_PWKPhJ_G0015250	protein coding gene	Chr1:62626074-62627866 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015030	protein coding gene	Chr1:65046780-65085550 (+)
WSB/EiJ	MGP_WSBEiJ_G0015526	protein coding gene	Chr1:65360279-65362538 (+)

Human Ortholog

CRYGD, crystallin gamma D

Vertebrate Orthologs

31

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRYGD, crystallin gamma D
Synonyms

CACA, CCA3, CCP, CRYG4, cry-g-D, CTRCT4, PCC
Links

HGNC:2411

NCBI Gene ID: 1421

neXtProt AC: NX_P07320

UniProt: P07320
Chr Location

2q33.3; chr2:208121607-208124524 (-) GRCh38

MGI Vertebrate Homology

Crygf stringent orthology
1 human;1 mouse;2 rat;28 zebrafish
HCOP

vertebrate homology predictions: CRYGD
Gene Tree

Crygf

Diseases

2 with human CRYGD associations

Human Disease

Mouse Models

cataract 4 multiple types

IDs

View 2 models

cataract 7

IDs

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Genomic Mutations

2 involving Crygf
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a chemically-induced single point mutation exhibit homogeneous cataracts while heterozygotes display less severe rays and concentric circles of lens opacity.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

11
cDNA Data

87
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS15018.1, CCDS87841.1

Ensembl

ENSMUSG00000025945 (Evidence)
NCBI Gene

12969

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025945	Ensembl Gene Model \| MGI Sequence Detail	1788	C57BL/6J	± kb
transcript	ENSMUST00000027082	Ensembl \| MGI Sequence Detail	627	Not Applicable
polypeptide	ENSMUSP00000027082	Ensembl \| MGI Sequence Detail	174	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006202 gamma-crystallin F

(term hierarchy)
InterPro Domains

IPR001064 Beta/gamma crystallin

IPR050252 Beta/Gamma-Crystallin

IPR011024 Gamma-crystallin-like

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All nucleic 98

Genomic 3

cDNA 88

Primer pair 6

Other 1

Microarray probesets 3

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MGD-MRK-2171, MGD-MRK-2181, MGD-MRK-8837, MGI:1916514

Summaries

All 65

Developmental Gene Expression 14

Gene Ontology 4

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:178731 Xie Q, et al., The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71

TSS for Crygf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7128	Chr1:65965678-65965682 (+)	1 bp
Tssr104	Chr1:65967370-65967379 (+)	1,696 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24