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Cryz Gene Detail
Summary
  • Symbol
    Cryz
  • Name
    crystallin, zeta
  • Synonyms
    quinone reductase, Sez9, SEZ9
  • Feature Type
    protein coding gene
  • IDs
    MGI:88527
    NCBI Gene: 12972
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:154302348-154328819 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 79.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    779 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88527
 protein coding gene Chr3:154302348-154328819 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028004
 protein coding gene Chr3:158613232-158643043 (+)
A/J MGP_AJ_G0027963
 protein coding gene Chr3:152823101-152850225 (+)
AKR/J MGP_AKRJ_G0027929
 protein coding gene Chr3:156911396-156939710 (+)
BALB/cJ MGP_BALBcJ_G0027975
 protein coding gene Chr3:152628873-152658751 (+)
C3H/HeJ MGP_C3HHeJ_G0027705
 protein coding gene Chr3:157285040-157311244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028418
 protein coding gene Chr3:163791295-163816497 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025756
 protein coding gene Chr3:147584381-147608997 (+)
CAST/EiJ MGP_CASTEiJ_G0027158
 protein coding gene Chr3:157411998-157438852 (+)
CBA/J MGP_CBAJ_G0027680
 protein coding gene Chr3:169682114-169708267 (+)
DBA/2J MGP_DBA2J_G0027820
 protein coding gene Chr3:151894639-151920432 (+)
FVB/NJ MGP_FVBNJ_G0027787
 protein coding gene Chr3:149269702-149294032 (+)
LP/J MGP_LPJ_G0027931
 protein coding gene Chr3:159934108-159960837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027820
 protein coding gene Chr3:178119879-178145551 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028477
 protein coding gene Chr3:156556767-156582218 (+)
PWK/PhJ MGP_PWKPhJ_G0026881
 protein coding gene Chr3:151825932-151854168 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026709
 protein coding gene Chr3:154718887-154745269 (+)
WSB/EiJ MGP_WSBEiJ_G0027238
 protein coding gene Chr3:157544956-157569820 (+)



Homology
more
  • Human Ortholog
    CRYZ, crystallin zeta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYZ, crystallin zeta
  • Links
    NCBI Gene ID: 1429
    neXtProt AC: NX_Q08257
    UniProt: Q08257

  • Chr Location
    1p31.1; chr1:74705482-74733408 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    112
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12972 NCBI Gene Model | MGI Sequence Detail 26472 C57BL/6J ±  kb
transcript NM_009968 RefSeq | MGI Sequence Detail 2519 C57BL/6  
polypeptide P47199 UniProt | EBI | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000005922 quinone oxidoreductase
    (term hierarchy)
  • EC
    1.6.5.5
  • InterPro Domains
    IPR013149 Alcohol dehydrogenase-like, C-terminal
    IPR013154 Alcohol dehydrogenase-like, N-terminal
    IPR011032 GroES-like superfamily
    IPR036291 NAD(P)-binding domain superfamily
    IPR020843 Polyketide synthase, enoylreductase domain
    IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site
    IPR051603 Zinc-Containing ADH Family: Quinone Oxidoreductase/CCCR
  • GlyGen
    P47199 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 115
    Genomic 3
    cDNA 112

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-2182
References
more
  • Summaries
    All 41
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:20118 Wistow G, et al., Recruitment of enzymes as lens structural proteins. Science. 1987 Jun 19;236(4808):1554-6
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory