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Csn1s1 Gene Detail
Summary
  • Symbol
    Csn1s1
  • Name
    casein alpha s1
  • Synonyms
    Csna
  • Feature Type
    protein coding gene
  • IDs
    MGI:88540
    NCBI Gene: 12990
  • Member of
    Csn cluster
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:87814067-87830437 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.56 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88540
 protein coding gene Chr5:87814067-87830437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029689
 protein coding gene Chr5:88617264-88634561 (+)
A/J MGP_AJ_G0029656
 protein coding gene Chr5:85000275-85016645 (+)
AKR/J MGP_AKRJ_G0029602
 protein coding gene Chr5:87813605-87829985 (+)
BALB/cJ MGP_BALBcJ_G0029665
 protein coding gene Chr5:85908051-85926469 (+)
C3H/HeJ MGP_C3HHeJ_G0029388
 protein coding gene Chr5:88226610-88243827 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030120
 protein coding gene Chr5:92255492-92274510 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027358
 protein coding gene Chr5:80627295-80643223 (+)
CAST/EiJ MGP_CASTEiJ_G0028798
 protein coding gene Chr5:87584611-87603410 (+)
CBA/J MGP_CBAJ_G0029357
 protein coding gene Chr5:95155299-95177180 (+)
DBA/2J MGP_DBA2J_G0029502
 protein coding gene Chr5:85178424-85194454 (+)
FVB/NJ MGP_FVBNJ_G0029462
 protein coding gene Chr5:84087850-84105711 (+)
LP/J MGP_LPJ_G0029590
 protein coding gene Chr5:89026235-89044964 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0030153
 protein coding gene Chr5:87377467-87395328 (+)
PWK/PhJ MGP_PWKPhJ_G0028517
 protein coding gene Chr5:84158304-84176826 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028355
 protein coding gene Chr5:86831898-86849012 (+)
WSB/EiJ MGP_WSBEiJ_G0028877
 protein coding gene Chr5:87768109-87785790 (+)



Homology
more
  • Human Ortholog
    CSN1S1, casein alpha s1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSN1S1, casein alpha s1
  • Synonyms
    CASA, CSN1
  • Links
    NCBI Gene ID: 1446
    neXtProt AC: NX_P47710
    UniProt: P47710

  • Chr Location
    4q13.3; chr4:69931068-69946574 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced milk prodution and abnormal milk composition with reduced protein, calcium and phosphate concentrations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    45
  • cDNA Data
    1900
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12990 NCBI Gene Model | MGI Sequence Detail 16371 C57BL/6J ±  kb
    transcript NM_007784 RefSeq | MGI Sequence Detail 1466 ZRU/MplStud  
    polypeptide P19228 UniProt | EBI | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1913
      Genomic 7
      cDNA 1903
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2198, MGI:2140790, MGI:2141176
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory