Csnk2a1 MGI Mouse Gene Detail - MGI:88543 - casein kinase 2, alpha 1 polypeptide

Symbol

Csnk2a1
Name

casein kinase 2, alpha 1 polypeptide
Synonyms

CK2, Csnk2a1-rs4

Feature Type

protein coding gene
IDs

MGI:88543
NCBI Gene: 12995
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:152068759-152123772 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.83 cM
Mapping Data

1 experiment

SNPs within 2kb

739 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88543	protein coding gene	Chr2:152068468-152123772 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026653	protein coding gene	Chr2:156755246-156808559 (+)
A/J	MGP_AJ_G0026619	protein coding gene	Chr2:150510841-150561615 (+)
AKR/J	MGP_AKRJ_G0026589	protein coding gene	Chr2:154904018-154958336 (+)
BALB/cJ	MGP_BALBcJ_G0026628	protein coding gene	Chr2:150822262-150873608 (+)
C3H/HeJ	MGP_C3HHeJ_G0026371	protein coding gene	Chr2:155294824-155343635 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027077	protein coding gene	Chr2:161331260-161389042 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024448	protein coding gene	Chr2:144108220-144155839 (+)
CAST/EiJ	MGP_CASTEiJ_G0025832	protein coding gene	Chr2:155515061-155563390 (+)
CBA/J	MGP_CBAJ_G0026349	protein coding gene	Chr2:167232287-167293511 (+)
DBA/2J	MGP_DBA2J_G0026485	protein coding gene	Chr2:149729497-149781351 (+)
FVB/NJ	MGP_FVBNJ_G0026450	protein coding gene	Chr2:148169733-148221577 (+)
LP/J	MGP_LPJ_G0026589	protein coding gene	Chr2:156926550-156978611 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026472	protein coding gene	Chr2:171358167-171411439 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027132	protein coding gene	Chr2:154778808-154831527 (+)
PWK/PhJ	MGP_PWKPhJ_G0025566	protein coding gene	Chr2:149247943-149299261 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025369	protein coding gene	Chr2:153622376-153669861 (+)
WSB/EiJ	MGP_WSBEiJ_G0025902	protein coding gene	Chr2:155713533-155764579 (+)

Human Ortholog

CSNK2A1, casein kinase 2 alpha 1

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSNK2A1, casein kinase 2 alpha 1
Synonyms

CK2A1, Cka1, Cka2, CKII, OCNDS
Links

HGNC:2457

NCBI Gene ID: 1457

neXtProt AC: NX_P68400

UniProt: P68400
Chr Location

20p13; chr20:472498-543835 (-) GRCh38

Human Ortholog

CSNK2A3, casein kinase 2 alpha 3
Synonyms

CSNK2A1P
Links

HGNC:2458

NCBI Gene ID: 283106

neXtProt AC: NX_Q8NEV1

UniProt: Q8NEV1
Chr Location

11p15.4; chr11:11351942-11353250 (-) GRCh38

MGI Vertebrate Homology

Csnk2a1 stringent orthology
2 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CSNK2A1, CSNK2A3
Gene Tree

Csnk2a1

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Phenotype Summary

32 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

84
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

74
Radiation induced

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Csnk2a1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

132 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for the null in the major catalytic subunit die by E11.5 and exhibit defects in neural, cardiac and limb development.

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All GO Annotations

77
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1038
Tissues

247
cDNA Data

118
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase csnk2a1

ZFIN csnk2a1

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All Sequences

83
RefSeq

26
UniProt

6
CCDS

CCDS16879.1

Ensembl

ENSMUSG00000074698 (Evidence)
NCBI Gene

12995

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074698	Ensembl Gene Model \| MGI Sequence Detail	55014	C57BL/6J	± kb
transcript	ENSMUST00000099224	Ensembl \| MGI Sequence Detail	4206	Not Applicable
polypeptide	ENSMUSP00000096829	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005950 casein kinase II subunit alpha

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR045216 Casein Kinase 2, subunit alpha

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q60737 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 127

Genomic 3

cDNA 120

Primer pair 3

Other 1

Microarray probesets 11

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MGD-MRK-2201, MGI:894650

Summaries

All 104

Developmental Gene Expression 19

Gene Ontology 15

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:332820 Merholz M, et al., In Skeletal Muscle Fibers, Protein Kinase Subunit CSNK2A1/CK2alpha Is Required for Proper Muscle Homeostasis and Structure and Function of Neuromuscular Junctions. Cells. 2022 Dec 7;11(24)

TSS for Csnk2a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20780	Chr2:152068460-152068494 (+)	-282 bp
Tssr20781	Chr2:152068728-152068759 (+)	-15 bp
Tssr20782	Chr2:152078654-152078658 (+)	9,897 bp
Tssr20783	Chr2:152085262-152085263 (+)	16,504 bp
Tssr20784	Chr2:152116000-152116006 (+)	47,244 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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