Csrp1 MGI Mouse Gene Detail - MGI:88549 - cysteine and glycine-rich protein 1

Symbol

Csrp1
Name

cysteine and glycine-rich protein 1
Synonyms

CRP1

Feature Type

protein coding gene
IDs

MGI:88549
NCBI Gene: 13007
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:135647799-135679970 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.23 cM
Mapping Data

4 experiments

SNPs within 2kb

1100 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88549	protein coding gene	Chr1:135614650-135679970 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016526	protein coding gene	Chr1:139498646-139535055 (+)
A/J	MGP_AJ_G0016509	protein coding gene	Chr1:134225578-134256390 (+)
AKR/J	MGP_AKRJ_G0016474	protein coding gene	Chr1:138213665-138248859 (+)
BALB/cJ	MGP_BALBcJ_G0016469	protein coding gene	Chr1:134544195-134576749 (+)
C3H/HeJ	MGP_C3HHeJ_G0016295	protein coding gene	Chr1:138318280-138349301 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016930	protein coding gene	Chr1:144529821-144564524 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014641	protein coding gene	Chr1:127326096-127359180 (+)
CAST/EiJ	MGP_CASTEiJ_G0015875	protein coding gene	Chr1:137399650-137432709 (+)
CBA/J	MGP_CBAJ_G0016268	protein coding gene	Chr1:149535837-149567658 (+)
DBA/2J	MGP_DBA2J_G0016374	protein coding gene	Chr1:133218332-133250244 (+)
FVB/NJ	MGP_FVBNJ_G0016373	protein coding gene	Chr1:131863384-131895280 (+)
LP/J	MGP_LPJ_G0016445	protein coding gene	Chr1:140735606-140768975 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016398	protein coding gene	Chr1:155187222-155220164 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016966	protein coding gene	Chr1:137986790-138019705 (+)
PWK/PhJ	MGP_PWKPhJ_G0015661	protein coding gene	Chr1:132254249-132287034 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015448	protein coding gene	Chr1:136963942-137001003 (+)
WSB/EiJ	MGP_WSBEiJ_G0015938	protein coding gene	Chr1:138020074-138053794 (+)

Human Ortholog

CSRP1, cysteine and glycine rich protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSRP1, cysteine and glycine rich protein 1
Synonyms

CRP, CRP1, CSRP, CYRP, D1S181E, HEL-141, HEL-S-286
Links

HGNC:2469

NCBI Gene ID: 1465

neXtProt AC: NX_P21291

UniProt: P21291
Chr Location

1q32.1; chr1:201483530-201509456 (-) GRCh38

MGI Vertebrate Homology

Csrp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CSRP1
Gene Tree

Csrp1

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

8
Radiation induced

1
Targeted

1
Genomic Mutations

3 involving Csrp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit decreased neointima formation following wire-induced arterial injury.

less

All GO Annotations

12
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1144
Tissues

279
cDNA Data

368
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase csrp1

ZFIN csrp1a

less

All Sequences

72
RefSeq

13
UniProt

2
CCDS

CCDS15320.1

Ensembl

ENSMUSG00000026421 (Evidence)
NCBI Gene

13007

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026421	Ensembl Gene Model \| MGI Sequence Detail	32172	C57BL/6J	± kb
transcript	ENSMUST00000097561	Ensembl \| MGI Sequence Detail	1828	Not Applicable
polypeptide	ENSMUSP00000095169	Ensembl \| MGI Sequence Detail	193	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000005958 cysteine and glycine-rich protein 1

(term hierarchy)
InterPro Domains

IPR001781 Zinc finger, LIM-type
GlyGen

P97315 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

less

All nucleic 376

cDNA 371

Primer pair 4

Other 1

Microarray probesets 5

less

MGD-MRK-2207, MGI:1353622, MGI:2138134, MGI:2138600

Summaries

All 63

Developmental Gene Expression 15

Gene Ontology 5

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Csrp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8967	Chr1:135647533-135647553 (+)	-256 bp
Tssr8968	Chr1:135656951-135656972 (+)	9,163 bp
Tssr8969	Chr1:135667212-135667220 (+)	19,417 bp
Tssr8970	Chr1:135668453-135668457 (+)	20,656 bp
Tssr222	Chr1:135674508-135674536 (+)	26,723 bp
Tssr8971	Chr1:135678336-135678353 (+)	30,546 bp
Tssr8972	Chr1:135678829-135678845 (+)	31,038 bp
Tssr8973	Chr1:135678908-135678948 (+)	31,129 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24