Ctsg MGI Mouse Gene Detail - MGI:88563

Symbol

Ctsg
Name

cathepsin G

Feature Type

protein coding gene
IDs

MGI:88563
NCBI Gene: 13035
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:56337342-56340031 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

5 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88563	protein coding gene	Chr14:56337338-56340031 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021384	protein coding gene	Chr14:50175285-50177978 (-)
A/J	MGP_AJ_G0021343	protein coding gene	Chr14:49179634-49182327 (-)
AKR/J	MGP_AKRJ_G0021319	protein coding gene	Chr14:50936350-50939043 (-)
BALB/cJ	MGP_BALBcJ_G0021346	protein coding gene	Chr14:49149837-49152530 (-)
C3H/HeJ	MGP_C3HHeJ_G0021127	protein coding gene	Chr14:50619798-50622491 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021786	protein coding gene	Chr14:52698088-52700781 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019328	protein coding gene	Chr14:47393134-47395789 (-)
CAST/EiJ	MGP_CASTEiJ_G0020646	protein coding gene	Chr14:46903200-46905826 (-)
CBA/J	MGP_CBAJ_G0021094	protein coding gene	Chr14:54241282-54243975 (-)
DBA/2J	MGP_DBA2J_G0021214	protein coding gene	Chr14:48902457-48905118 (-)
FVB/NJ	MGP_FVBNJ_G0021197	protein coding gene	Chr14:48317944-48320636 (-)
LP/J	MGP_LPJ_G0021289	protein coding gene	Chr14:51217915-51220608 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021221	protein coding gene	Chr14:53602339-53605031 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021812	protein coding gene	Chr14:50122910-50125603 (-)
PWK/PhJ	MGP_PWKPhJ_G0020390	protein coding gene	Chr14:45425859-45428552 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020220	protein coding gene	Chr14:46179501-46182188 (-)
WSB/EiJ	MGP_WSBEiJ_G0020699	protein coding gene	Chr14:50379956-50382648 (-)

Human Ortholog

CTSG, cathepsin G

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTSG, cathepsin G
Synonyms

CATG, CG
Links

HGNC:2532

NCBI Gene ID: 1511

neXtProt AC: NX_P08311

UniProt: P08311
Chr Location

14q12; chr14:24573518-24576250 (-) GRCh38

MGI Vertebrate Homology

Ctsg stringent orthology
1 human;1 mouse;4 zebrafish
HCOP

vertebrate homology predictions: CTSG
Gene Tree

Ctsg

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Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
19 phenotypes from multigenic genotypes
49 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

1 involving Ctsg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygous for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.

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All GO Annotations

62
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

1
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctsg

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All Sequences

33
RefSeq

2
UniProt

2
CCDS

CCDS27142.1

Ensembl

ENSMUSG00000040314 (Evidence)
NCBI Gene

13035

			Length	Strain/Species	Flank
genomic	13035	NCBI Gene Model \| MGI Sequence Detail	2690	C57BL/6J	± kb
transcript	NM_007800	RefSeq \| MGI Sequence Detail	1015	ZRU/MplStud
polypeptide	P28293	UniProt \| EBI \| MGI Sequence Detail	261	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006028 cathepsin G

(term hierarchy)
EC

3.4.21.20
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

P28293 2 sites, 1 O-linked glycan (1 site)

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All nucleic 24

Genomic 7

cDNA 16

Other 1

Microarray probesets 2

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MGD-MRK-2247

Summaries

All 84

Developmental Gene Expression 2

Diseases 2

Gene Ontology 10

Phenotypes 49
Earliest

J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
Latest

J:341196 Yang WH, et al., Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis. iScience. 2023 Oct 20;26(10):107883

TSS for Ctsg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128913	Chr14:56339915-56339929 (-)	109 bp
Tssr128912	Chr14:56338170-56338180 (-)	1,856 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24