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Cux1 Gene Detail
Summary
  • Symbol
    Cux1
  • Name
    cut-like homeobox 1
  • Synonyms
    CDP, Cutl1, Cux, Cux-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88568
    NCBI Gene: 13047
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136276989-136596344 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.96 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5582 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88568
 protein coding gene Chr5:136276989-136596429 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030206
 protein coding gene Chr5:140892620-141228488 (-)
A/J MGP_AJ_G0030174
 protein coding gene Chr5:134810440-135135445 (-)
AKR/J MGP_AKRJ_G0030107
 protein coding gene Chr5:139164582-139495695 (-)
BALB/cJ MGP_BALBcJ_G0030184
 protein coding gene Chr5:136170302-136491285 (-)
C3H/HeJ MGP_C3HHeJ_G0029900
 protein coding gene Chr5:139788572-140117113 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030637
 protein coding gene Chr5:146117913-146470279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027857
 protein coding gene Chr5:129090907-129411666 (-)
CAST/EiJ MGP_CASTEiJ_G0029310
 protein coding gene Chr5:139188884-139518946 (-)
CBA/J MGP_CBAJ_G0029870
 protein coding gene Chr5:151832829-152175551 (-)
DBA/2J MGP_DBA2J_G0030021
 protein coding gene Chr5:134710045-135033046 (-)
FVB/NJ MGP_FVBNJ_G0029976
 protein coding gene Chr5:133865654-134195466 (-)
LP/J MGP_LPJ_G0030110
 protein coding gene Chr5:141307553-141655184 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030008
 protein coding gene Chr5:154797060-155133405 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030677
 protein coding gene Chr5:138988725-139317233 (-)
PWK/PhJ MGP_PWKPhJ_G0029023
 protein coding gene Chr5:133777805-134107531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028859
 protein coding gene Chr5:136547215-136897169 (-)
WSB/EiJ MGP_WSBEiJ_G0029383
 protein coding gene Chr5:139724104-140051431 (-)



Homology
more
  • Human Ortholog
    CUX1, cut like homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUX1, cut like homeobox 1
  • Synonyms
    CASP, CDP, CDP1, CDP/Cut, Clox, COY1, CUTL1, CUX, Cux/CDP, GDDI, GOLIM6, Nbla10317, p100, p110, p200, p75
  • Links
    NCBI Gene ID: 1523
    neXtProt AC: NX_P39880, NX_Q13948
    UniProt: P39880, Q13948

  • Chr Location
    7q22.1; chr7:101815904-102283958 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 9 genetic backgrounds
    7 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1471
  • Tissues
    319
  • cDNA Data
    34
  • Literature Summary
    469
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029705 Ensembl Gene Model | MGI Sequence Detail 319356 C57BL/6J ±  kb
    transcript ENSMUST00000176172 Ensembl | MGI Sequence Detail 4882 Not Applicable  
    polypeptide ENSMUSP00000135086 Ensembl | MGI Sequence Detail 1517 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 39
      Primer pair 6
      Other 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-2253, MGI:2140722
    References
    more
    • Summaries
      All 546
      Developmental Gene Expression 469
      Gene Ontology 15
      Phenotypes 36
    • Earliest
      J:11951 Andres V, et al., Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development. Development. 1992 Oct;116(2):321-34
    • Latest
      J:358491 Zhao B, et al., The homeobox transcription factor Cux1 coordinates postnatal epithelial developmental timing but is dispensable for lung organogenesis and regeneration. bioRxiv. 2024;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory