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Cyp11b1 Gene Detail
Summary
  • Symbol
    Cyp11b1
  • Name
    cytochrome P450, family 11, subfamily b, polypeptide 1
  • Synonyms
    Cyp11b, Cyp11b-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88583
    NCBI Gene: 110115
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:74706741-74713492 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 34.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88583
 protein coding gene Chr15:74705974-74713492 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021942
 protein coding gene Chr15:74623753-74634083 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0021883
 protein coding gene Chr15:73818724-73826636 (-)
BALB/cJ MGP_BALBcJ_G0021908
 protein coding gene Chr15:71973698-71995102 (-)
C3H/HeJ MGP_C3HHeJ_G0021681
 protein coding gene Chr15:73967715-73977492 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022348
 protein coding gene Chr15:77445222-77454664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019883
 protein coding gene Chr15:68361004-68368419 (-)
CAST/EiJ MGP_CASTEiJ_G0021200
 protein coding gene Chr15:74789189-74801972 (-)
CBA/J MGP_CBAJ_G0021647
 protein coding gene Chr15:79984832-79995333 (-)
DBA/2J MGP_DBA2J_G0021772
 protein coding gene Chr15:71558570-71566456 (-)
FVB/NJ MGP_FVBNJ_G0021754
 protein coding gene Chr15:70599906-70607190 (-)
LP/J MGP_LPJ_G0021844
 protein coding gene Chr15:74699819-74708587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021777
 protein coding gene Chr15:85282165-85290995 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022369
 protein coding gene Chr15:74200595-74213220 (-)
PWK/PhJ MGP_PWKPhJ_G0020939
 protein coding gene Chr15:71664238-71690587 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020780
 protein coding gene Chr15:74051476-74058209 (+)
WSB/EiJ MGP_WSBEiJ_G0021252
 protein coding gene Chr15:74216002-74231371 (-)



Homology
more
  • Human Ortholog
    CYP11B1, cytochrome P450 family 11 subfamily B member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP11B1, cytochrome P450 family 11 subfamily B member 1
  • Synonyms
    CPN1, CYP11B, FHI, P450C11
  • Links
    NCBI Gene ID: 1584
    neXtProt AC: NX_P15538
    UniProt: P15538

  • Chr Location
    8q24.3; chr8:142872356-142879846 (-)  GRCh38
  • Human Ortholog
    CYP11B2, cytochrome P450 family 11 subfamily B member 2
  • Synonyms
    ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P450aldo, P-450C18, P450C18
  • Links
    NCBI Gene ID: 1585
    neXtProt AC: NX_P19099
    UniProt: P19099

  • Chr Location
    8q24.3; chr8:142910559-142917843 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cyp11b1 mouse models; 9 with human CYP11B1,CYP11B2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    2 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit adrenal hypertrophy, abnormal organ weights, abnormal hormone levels, abnormal urine chemistry, hypokalemia, increased blood pressure, and female infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    108
  • cDNA Data
    11
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110115 NCBI Gene Model | MGI Sequence Detail 6752 C57BL/6J ±  kb
    transcript NM_001033229 RefSeq | MGI Sequence Detail 2373 C57BL/6  
    polypeptide NP_001028401 RefSeq | MGI Sequence Detail 499 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 12
      Primer pair 8
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-2292, MGD-MRK-2293, MGD-MRK-2295, MGI:3035249
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 31
      Diseases 2
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory