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Cyp1a2 Gene Detail
Summary
  • Symbol
    Cyp1a2
  • Name
    cytochrome P450, family 1, subfamily a, polypeptide 2
  • Synonyms
    aromatic compound inducible, CP12, P450-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88589
    NCBI Gene: 13077
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57584220-57590938 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.30 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    239 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    6
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88589
 protein coding gene Chr9:57584220-57590986 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034875
 protein coding gene Chr9:56906747-56913457 (-)
A/J MGP_AJ_G0034856
 protein coding gene Chr9:55064230-55071567 (-)
AKR/J MGP_AKRJ_G0034785
 protein coding gene Chr9:56331988-56338706 (-)
BALB/cJ MGP_BALBcJ_G0034848
 protein coding gene Chr9:54849452-54856170 (-)
C3H/HeJ MGP_C3HHeJ_G0034558
 protein coding gene Chr9:56817144-56823869 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035367
 protein coding gene Chr9:58495922-58502640 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032278
 protein coding gene Chr9:54368478-54375410 (-)
CAST/EiJ MGP_CASTEiJ_G0033879
 protein coding gene Chr9:56917066-56923796 (-)
CBA/J MGP_CBAJ_G0034529
 protein coding gene Chr9:60528430-60535149 (-)
DBA/2J MGP_DBA2J_G0034688
 protein coding gene Chr9:54931213-54937921 (-)
FVB/NJ MGP_FVBNJ_G0034630
 protein coding gene Chr9:54161800-54168507 (-)
LP/J MGP_LPJ_G0034771
 protein coding gene Chr9:57204683-57211393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034673
 protein coding gene Chr9:62026728-62033438 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035389
 protein coding gene Chr9:56353218-56359939 (-)
PWK/PhJ MGP_PWKPhJ_G0033584
 protein coding gene Chr9:54969591-54976322 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033418
 protein coding gene Chr9:56646976-56653665 (-)
WSB/EiJ MGP_WSBEiJ_G0033992
 protein coding gene Chr9:56291450-56298171 (-)



Homology
more
  • Human Ortholog
    CYP1A2, cytochrome P450 family 1 subfamily A member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP1A2, cytochrome P450 family 1 subfamily A member 2
  • Synonyms
    CP12, CYPIA2, P3-450, P450(PA)
  • Links
    NCBI Gene ID: 1544
    neXtProt AC: NX_P05177
    UniProt: P05177

  • Chr Location
    15q24.1; chr15:74748845-74756607 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CYP1A2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display resitance to some signs of TCDD induced toxicity but do not display any gross abnormalities in the abscence of treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    107
  • cDNA Data
    110
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13077 NCBI Gene Model | MGI Sequence Detail 6719 C57BL/6J ±  kb
    transcript NM_009993 RefSeq | MGI Sequence Detail 1892 Not Specified  
    polypeptide P00186 UniProt | EBI | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      Genomic 4
      cDNA 111
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13112, MGD-MRK-2303
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 7
      Gene Ontology 20
      Phenotypes 64
    • Earliest
      J:31549 Negishi M, et al., Isolation and characterization of a cloned DNA sequence associated with the murine Ah locus and a 3-methylcholanthrene-induced form of cytochrome P-450. Proc Natl Acad Sci U S A. 1981 Feb;78(2):800-4
    • Latest
      J:344332 Stading R, et al., Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med. 2024 Feb 1;211:35-46
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory