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Cyp24a1 Gene Detail
Summary
  • Symbol
    Cyp24a1
  • Name
    cytochrome P450, family 24, subfamily a, polypeptide 1
  • Synonyms
    24-OHase, 25-hydroxyvitamin D-24-hydroxylase, CP24, Cyp24
  • Feature Type
    protein coding gene
  • IDs
    MGI:88593
    NCBI Gene: 13081
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:170324877-170339065 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 91.91 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88593
 protein coding gene Chr2:170324628-170339065 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026935
 protein coding gene Chr2:176533573-176547730 (-)
A/J MGP_AJ_G0026902
 protein coding gene Chr2:169161174-169176296 (-)
AKR/J MGP_AKRJ_G0026873
 protein coding gene Chr2:174223633-174238605 (-)
BALB/cJ MGP_BALBcJ_G0026911
 protein coding gene Chr2:169535771-169550582 (-)
C3H/HeJ MGP_C3HHeJ_G0026653
 protein coding gene Chr2:174594893-174610744 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027358
 protein coding gene Chr2:181629518-181643780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024728
 protein coding gene Chr2:162454409-162469919 (-)
CAST/EiJ MGP_CASTEiJ_G0026111
 protein coding gene Chr2:175202847-175219902 (-)
CBA/J MGP_CBAJ_G0026630
 protein coding gene Chr2:188402706-188417051 (-)
DBA/2J MGP_DBA2J_G0026768
 protein coding gene Chr2:168254137-168268532 (-)
FVB/NJ MGP_FVBNJ_G0026734
 protein coding gene Chr2:166856905-166871517 (-)
LP/J MGP_LPJ_G0026869
 protein coding gene Chr2:176482120-176499114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026753
 protein coding gene Chr2:191499074-191513866 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027415
 protein coding gene Chr2:174185890-174200905 (-)
PWK/PhJ MGP_PWKPhJ_G0025848
 protein coding gene Chr2:167978535-167993310 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025648
 protein coding gene Chr2:173189978-173205430 (-)
WSB/EiJ MGP_WSBEiJ_G0026184
 protein coding gene Chr2:175142522-175158037 (-)



Homology
more
  • Human Ortholog
    CYP24A1, cytochrome P450 family 24 subfamily A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP24A1, cytochrome P450 family 24 subfamily A member 1
  • Synonyms
    CP24, CYP24, HCAI, HCINF1, P450-CC24
  • Links
    NCBI Gene ID: 1591
    neXtProt AC: NX_Q07973
    UniProt: Q07973

  • Chr Location
    20q13.2; chr20:54143538-54173986 (-)  GRCh38
Human Diseases
more
  • Diseases
    14 with human CYP24A1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene suffer a 50% mortality rate between birth and weaning. abnormalities are seen in the development of membranous bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    110
  • cDNA Data
    21
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13081 NCBI Gene Model | MGI Sequence Detail 14189 C57BL/6J ±  kb
    transcript NM_009996 RefSeq | MGI Sequence Detail 3311 ZRU/MplStud  
    polypeptide Q64441 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 21
      Primer pair 4
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-2310
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:20133 Malas S, et al., The genes for endothelin 3, vitamin d 24-hydroxylase, and melanocortin 3 receptor map to distal mouse chromosome 2, in the region of conserved synteny with human chromosome 20. Mamm Genome. 1994;5:577-579
    • Latest
      J:295400 Singh A, et al., Noncoding variations in Cyp24a1 gene are associated with Klotho-mediated aging phenotypes in different strains of mice. Aging Cell. 2019 Jun;18(3):e12949
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory