About   Help   FAQ
Cyp4a12a Gene Detail
Summary
  • Symbol
    Cyp4a12a
  • Name
    cytochrome P450, family 4, subfamily a, polypeptide 12a
  • Synonyms
    Cyp4a12
  • Feature Type
    protein coding gene
  • IDs
    MGI:88612
    NCBI Gene: 277753
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115156243-115190012 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 52.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    980 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88612
 protein coding gene Chr4:115156243-115190012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028598
 protein coding gene Chr4:116209094-116239047 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0028508
 protein coding gene Chr4:113974781-114011784 (+)
BALB/cJ MGP_BALBcJ_G0028580
 protein coding gene Chr4:112392345-112419312 (+)
C3H/HeJ MGP_C3HHeJ_G0028294
 protein coding gene Chr4:115561873-115616616 (+)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0026308
 protein coding gene Chr4:105733284-105754714 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028261
 protein coding gene Chr4:123747594-123782353 (+)
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0028512
 protein coding gene Chr4:116358342-116398569 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028404
 protein coding gene Chr4:128873670-128917968 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029060
 protein coding gene Chr4:115329394-115351419 (+)
PWK/PhJ MGP_PWKPhJ_G0027456
 protein coding gene Chr4:109191408-109226964 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027280
 protein coding gene Chr4:111642217-111662667 (+)
WSB/EiJ MGP_WSBEiJ_G0027810
 protein coding gene Chr4:115173338-115193887 (+)



Homology
more
  • Human Ortholog
    CYP4A11, cytochrome P450 family 4 subfamily A member 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP4A11, cytochrome P450 family 4 subfamily A member 11
  • Synonyms
    CP4Y, CYP4A2, CYP4AII, CYPIVA11
  • Links
    NCBI Gene ID: 1579
    neXtProt AC: NX_Q02928
    UniProt: Q02928

  • Chr Location
    1p33; chr1:46929177-46941484 (-)  GRCh38
  • Human Ortholog
    CYP4A22, cytochrome P450 family 4 subfamily A member 22
  • Links
    NCBI Gene ID: 284541
    neXtProt AC: NX_Q5TCH4
    UniProt: Q5TCH4

  • Chr Location
    1p33; chr1:47137435-47149727 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CYP4A11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    114
  • cDNA Data
    52
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 277753 NCBI Gene Model | MGI Sequence Detail 33770 C57BL/6J ±  kb
transcript NM_177406 RefSeq | MGI Sequence Detail 2422 FVB/N  
polypeptide Q91WL5 UniProt | EBI | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 58
    Genomic 2
    cDNA 54
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-2335, MGI:3611576
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:4152 Nelson DR, et al., The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 1993 Jan-Feb;12(1):1-51
  • Latest
    J:308925 Chikada H, et al., Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism. Lab Invest. 2018 Nov;98(11):1500-1511
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory