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Ccn1 Gene Detail
Summary
  • Symbol
    Ccn1
  • Name
    cellular communication network factor 1
  • Synonyms
    CCN1, Cyr61
  • Feature Type
    protein coding gene
  • IDs
    MGI:88613
    NCBI Gene: 16007
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:145352731-145355736 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 70.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88613
 protein coding gene Chr3:145352726-145355740 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027961
 protein coding gene Chr3:149081671-149084679 (-)
A/J MGP_AJ_G0027920
 protein coding gene Chr3:143769533-143772193 (-)
AKR/J MGP_AKRJ_G0027886
 protein coding gene Chr3:147579852-147582858 (-)
BALB/cJ MGP_BALBcJ_G0027932
 protein coding gene Chr3:143580965-143583972 (-)
C3H/HeJ MGP_C3HHeJ_G0027662
 protein coding gene Chr3:147951092-147954136 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028375
 protein coding gene Chr3:154163800-154166836 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025714
 protein coding gene Chr3:138851676-138854694 (-)
CAST/EiJ MGP_CASTEiJ_G0027115
 protein coding gene Chr3:147913750-147916772 (-)
CBA/J MGP_CBAJ_G0027637
 protein coding gene Chr3:159545922-159548928 (-)
DBA/2J MGP_DBA2J_G0027777
 protein coding gene Chr3:142921093-142924097 (-)
FVB/NJ MGP_FVBNJ_G0027744
 protein coding gene Chr3:140328634-140331637 (-)
LP/J MGP_LPJ_G0027888
 protein coding gene Chr3:150469601-150472609 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027777
 protein coding gene Chr3:167860182-167863190 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028434
 protein coding gene Chr3:147175256-147178263 (-)
PWK/PhJ MGP_PWKPhJ_G0026838
 protein coding gene Chr3:142763978-142766994 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026666
 protein coding gene Chr3:145360693-145363708 (-)
WSB/EiJ MGP_WSBEiJ_G0027195
 protein coding gene Chr3:148137064-148140068 (-)



Homology
more
  • Human Ortholog
    CCN1, cellular communication network factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCN1, cellular communication network factor 1
  • Synonyms
    CYR61, GIG1, IGFBP10
  • Links
    NCBI Gene ID: 3491
    neXtProt AC: NX_O00622
    UniProt: O00622

  • Chr Location
    1p22.3; chr1:85580761-85584589 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ccn1 mouse models; 1 with human CCN1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mice die pre- or perinatally, and none survive beyond 24 hrs of birth. About 30% of embryos die by E10.5 from defects in chorioallantoic fusion, whereas 70% die from placental vascular defects, including impaired allantoic vessel bifurcation, and loss of large-vessel integrity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    173
  • cDNA Data
    113
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028195 Ensembl Gene Model | MGI Sequence Detail 3006 C57BL/6J ±  kb
    transcript ENSMUST00000029846 Ensembl | MGI Sequence Detail 2019 Not Applicable  
    polypeptide ENSMUSP00000029846 Ensembl | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 128
      Genomic 2
      cDNA 113
      Primer pair 11
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-2336, MGI:2139677, MGI:6209563
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 57
      Diseases 2
      Gene Ontology 15
      Phenotypes 29
    • Earliest
      J:34028 O'Brien TP, et al., Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990 Jul;10(7):3569-77
    • Latest
      J:339839 Ross JA, et al., Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory