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Bhlha15 Gene Detail
Summary
  • Symbol
    Bhlha15
  • Name
    basic helix-loop-helix family, member a15
  • Synonyms
    1810009C13Rik, Bhlhb8, Mist1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891976
    NCBI Gene: 17341
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:144127104-144131259 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 83.05 cM, cytoband G2-G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891976
 protein coding gene Chr5:144127104-144131259 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030346
 protein coding gene Chr5:149514095-149518220 (+)
A/J MGP_AJ_G0030315
 protein coding gene Chr5:143099590-143103715 (+)
AKR/J MGP_AKRJ_G0030247
 protein coding gene Chr5:147554655-147558788 (+)
BALB/cJ MGP_BALBcJ_G0030332
 protein coding gene Chr5:144344773-144348898 (+)
C3H/HeJ MGP_C3HHeJ_G0030043
 protein coding gene Chr5:148397939-148402056 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030777
 protein coding gene Chr5:154988267-154992390 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027996
 protein coding gene Chr5:136888026-136892042 (+)
CAST/EiJ MGP_CASTEiJ_G0029448
 protein coding gene Chr5:147918921-147923068 (+)
CBA/J MGP_CBAJ_G0030013
 protein coding gene Chr5:161347103-161351252 (+)
DBA/2J MGP_DBA2J_G0030163
 protein coding gene Chr5:142849824-142853943 (+)
FVB/NJ MGP_FVBNJ_G0030118
 protein coding gene Chr5:142068361-142072654 (+)
LP/J MGP_LPJ_G0030249
 protein coding gene Chr5:150127397-150131530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030149
 protein coding gene Chr5:163718393-163722514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030817
 protein coding gene Chr5:147443489-147447610 (+)
PWK/PhJ MGP_PWKPhJ_G0029163
 protein coding gene Chr5:141960464-141964581 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028999
 protein coding gene Chr5:145180672-145184769 (+)
WSB/EiJ MGP_WSBEiJ_G0029521
 protein coding gene Chr5:148251457-148255577 (+)



Homology
more
  • Human Ortholog
    BHLHA15, basic helix-loop-helix family member a15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BHLHA15, basic helix-loop-helix family member a15
  • Synonyms
    BHLHB8, MIST1
  • Links
    NCBI Gene ID: 168620
    neXtProt AC: NX_Q7RTS1
    UniProt: Q7RTS1

  • Chr Location
    7q21.3; chr7:98211439-98215457 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a generally normal phenotype. Abnormalities exist in the acinar cells of various glands and become progressively worse with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    138
  • cDNA Data
    37
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17341 NCBI Gene Model | MGI Sequence Detail 4156 C57BL/6J ±  kb
    transcript NM_010800 RefSeq | MGI Sequence Detail 3494 C57BL/6  
    polypeptide Q9QYC3 UniProt | EBI | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004736 class A basic helix-loop-helix protein 15
      (term hierarchy)
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 1
      cDNA 37
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916361
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 46
      Gene Ontology 13
      Phenotypes 70
    • Earliest
      J:39063 Lemercier C, et al., Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol. 1997 Feb 1;182(1):101-13
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory