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Phyh Gene Detail
Summary
  • Symbol
    Phyh
  • Name
    phytanoyl-CoA hydroxylase
  • Synonyms
    Lnap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:891978
    NCBI Gene: 16922
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:4923830-4943541 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 3.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    611 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_891978
 protein coding gene Chr2:4923807-4943554 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025317
 protein coding gene Chr2:1998443-2026743 (+)
A/J MGP_AJ_G0025294
 protein coding gene Chr2:1898953-1918428 (+)
AKR/J MGP_AKRJ_G0025262
 protein coding gene Chr2:1936774-1960058 (+)
BALB/cJ MGP_BALBcJ_G0025290
 protein coding gene Chr2:1880267-1900319 (+)
C3H/HeJ MGP_C3HHeJ_G0025050
 protein coding gene Chr2:1928713-1948472 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025732
 protein coding gene Chr2:2014888-2038192 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023146
 protein coding gene Chr2:1748451-1771741 (+)
CAST/EiJ MGP_CASTEiJ_G0024513
 protein coding gene Chr2:1957757-1977992 (+)
CBA/J MGP_CBAJ_G0025029
 protein coding gene Chr2:2098995-2125430 (+)
DBA/2J MGP_DBA2J_G0025161
 protein coding gene Chr2:1867318-1888296 (+)
FVB/NJ MGP_FVBNJ_G0025123
 protein coding gene Chr2:1856622-1877736 (+)
LP/J MGP_LPJ_G0025247
 protein coding gene Chr2:1976308-2003463 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025155
 protein coding gene Chr2:2002089-2029235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025790
 protein coding gene Chr2:1941403-1963356 (+)
PWK/PhJ MGP_PWKPhJ_G0024263
 protein coding gene Chr2:1848894-1868699 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024064
 protein coding gene Chr2:1943285-2036490 (+)
WSB/EiJ MGP_WSBEiJ_G0024583
 protein coding gene Chr2:1960448-1980877 (+)



Homology
more
  • Human Ortholog
    PHYH, phytanoyl-CoA 2-hydroxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHYH, phytanoyl-CoA 2-hydroxylase
  • Synonyms
    LN1, LNAP1, PAHX, PHYH1, RD
  • Links
    NCBI Gene ID: 5264
    neXtProt AC: NX_O14832
    UniProt: O14832

  • Chr Location
    10p13; chr10:13277796-13302412 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Phyh mouse models; 4 with human PHYH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When fed a high phytol diet, mice homozygous for a null allele exhibit hepatic lipidosis and steatosis, ataxia, peripheral neuropathy and loss of spermatogonia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    143
  • cDNA Data
    173
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026664 Ensembl Gene Model | MGI Sequence Detail 19712 C57BL/6J ±  kb
    transcript ENSMUST00000027975 Ensembl | MGI Sequence Detail 1438 Not Applicable  
    polypeptide ENSMUSP00000027975 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      cDNA 173

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138869, MGI:2138872
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:37950 Iwano M, et al., Molecular cloning and expression of a novel peptide (LN1) gene: reduced expression in the renal cortex of lupus nephritis in MRL/lpr mouse. Biochem Biophys Res Commun. 1996 Dec 4;229(1):355-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory