Gykl1 MGI Mouse Gene Detail - MGI:891990

Symbol

Gykl1
Name

glycerol kinase-like 1
Synonyms

Gk-rs1

Feature Type

protein coding gene
IDs

MGI:891990
NCBI Gene: 14625
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr18:52826762-52828622 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 28.25 cM
Mapping Data

5 experiments

SNPs within 2kb

85 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_891990	protein coding gene	Chr18:52826751-52828665 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024431	protein coding gene	Chr18:51821340-51823329 (+)
A/J	MGP_AJ_G0024397	protein coding gene	Chr18:49830244-49832233 (+)
AKR/J	MGP_AKRJ_G0024367	protein coding gene	Chr18:51218315-51220304 (+)
BALB/cJ	MGP_BALBcJ_G0024397	protein coding gene	Chr18:50013260-50015249 (+)
C3H/HeJ	MGP_C3HHeJ_G0024164	protein coding gene	Chr18:51352917-51354906 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024843	protein coding gene	Chr18:53580199-53582188 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022275	protein coding gene	Chr18:49618271-49620261 (+)
CAST/EiJ	MGP_CASTEiJ_G0023638	protein coding gene	Chr18:51318865-51320854 (+)
CBA/J	MGP_CBAJ_G0024134	protein coding gene	Chr18:55147140-55149129 (+)
DBA/2J	MGP_DBA2J_G0024264	protein coding gene	Chr18:49535482-49537471 (+)
FVB/NJ	MGP_FVBNJ_G0024231	protein coding gene	Chr18:48961353-48963342 (+)
LP/J	MGP_LPJ_G0024349	protein coding gene	Chr18:51854466-51856455 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024261	protein coding gene	Chr18:56905917-56907906 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024890	protein coding gene	Chr18:51233515-51235504 (+)
PWK/PhJ	MGP_PWKPhJ_G0023382	protein coding gene	Chr18:49532439-49534428 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023188	protein coding gene	Chr18:51414319-51416308 (+)
WSB/EiJ	MGP_WSBEiJ_G0023701	protein coding gene	Chr18:51150005-51151994 (+)

Human Ortholog

GK, glycerol kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GK, glycerol kinase
Synonyms

GK1, GKD
Links

HGNC:4289

NCBI Gene ID: 2710

neXtProt AC: NX_P32189

UniProt: P32189
Chr Location

Xp21.2; chrX:30653359-30731462 (+) GRCh38

MGI Vertebrate Homology

Gykl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GK
Protein SuperFamily

GlpK
Gene Tree

Gykl1

Diseases

1 with human GK associations

Human Disease

Mouse Models

glycerol kinase deficiency

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

6
Spontaneous

1
Genomic Mutations

1 involving Gykl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

The gene product is involved in mitochondrial dynamics in sperm cells. Homozygous KO causes sperm motility defects which leads to male infertility.

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All GO Annotations

13
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

25

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

3
CCDS

CCDS29250.1

Ensembl

ENSMUSG00000053624 (Evidence)
NCBI Gene

14625

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053624	Ensembl Gene Model \| MGI Sequence Detail	1861	C57BL/6J	± kb
transcript	ENSMUST00000066193	Ensembl \| MGI Sequence Detail	1861	Not Applicable
polypeptide	ENSMUSP00000067598	Ensembl \| MGI Sequence Detail	549	Not Applicable

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UniProt

3 Sequences
EC

2.7.1.30
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR000577 Carbohydrate kinase, FGGY

IPR018483 Carbohydrate kinase, FGGY, conserved site

IPR018485 Carbohydrate kinase FGGY, C-terminal

IPR018484 Carbohydrate kinase FGGY, N-terminal

IPR005999 Glycerol kinase

IPR042018 Glycerol kinase, metazoa

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All nucleic 26

Genomic 1

cDNA 25

Microarray probesets 3

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MGI:2147227

Summaries

All 30

Gene Ontology 3

Phenotypes 6
Earliest

J:40192 Dixon J, et al., Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1. Hum Mol Genet. 1997 May;6(5):727-37
Latest

J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67

TSS for Gykl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151059	Chr18:52826739-52826742 (+)	-21 bp
Tssr151060	Chr18:52826754-52826785 (+)	8 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24