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Klk1b1 Gene Detail
Summary
  • Symbol
    Klk1b1
  • Name
    kallikrein 1-related peptidase b1
  • Synonyms
    Klk1, mGK-1, mK1, tissue kallikrein, TK
  • Feature Type
    protein coding gene
  • IDs
    MGI:892019
    NCBI Gene: 16623
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43616175-43620742 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.44 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    423 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892019
 protein coding gene Chr7:43616175-43620742 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032150
 protein coding gene Chr7:44026918-44031889 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0032067
 protein coding gene Chr7:44495725-44500292 (+)
BALB/cJ MGP_BALBcJ_G0032142
 protein coding gene Chr7:43312955-43317518 (+)
C3H/HeJ MGP_C3HHeJ_G0031857
 protein coding gene Chr7:44992789-44997356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032624
 protein coding gene Chr7:46265988-46275779 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029652
 protein coding gene Chr7:45867182-45871713 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031976
 protein coding gene Chr7:42911413-42915983 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0032052
 protein coding gene Chr7:44763092-44769353 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0032645
 protein coding gene Chr7:43622722-43627293 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030746
 protein coding gene Chr7:31661862-31663937 (+)
WSB/EiJ MGP_WSBEiJ_G0031304
 protein coding gene Chr7:44189955-44192005 (+)



Homology
more
  • Human Ortholog
    KLK1, kallikrein 1
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK1, kallikrein 1
  • Synonyms
    hK1, Klk6, KLKR
  • Links
    NCBI Gene ID: 3816
    neXtProt AC: NX_P06870
    UniProt: P06870

  • Chr Location
    19q13.33; chr19:50819146-50823787 (-)  GRCh38
  • Human Ortholog
    KLK2, kallikrein related peptidase 2
  • Synonyms
    hGK-1, hK2, KLK2A2
  • Links
    NCBI Gene ID: 3817
    neXtProt AC: NX_P20151
    UniProt: P20151

  • Chr Location
    19q13.33; chr19:50861568-50880567 (+)  GRCh38
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288
    UniProt: P07288

  • Chr Location
    19q13.33; chr19:50854915-50860764 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human KLK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Homozygous null mice display decreased left ventricular contractility, cardiac output, and stroke volume, a thin left ventricular wall, and impaired vasodilation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16623 NCBI Gene Model | MGI Sequence Detail 4568 C57BL/6J ±  kb
transcript NM_010645 RefSeq | MGI Sequence Detail 867 ZRU/MplStud  
polypeptide P00755 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 93
    Genomic 82
    cDNA 10
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 42
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:32312 Richards RI, et al., Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases. J Biol Chem. 1982 Mar 25;257(6):2758-61
  • Latest
    J:256467 Desposito D, et al., Neuroprotective effect of kinin B1 receptor activation in acute cerebral ischemia in diabetic mice. Sci Rep. 2017 Aug 25;7(1):9410
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory