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Frzb Gene Detail
Summary
  • Symbol
    Frzb
  • Name
    frizzled-related protein
  • Synonyms
    fritz, Frp, frzb-1, Sfrp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:892032
    NCBI Gene: 20378
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:80242314-80277740 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 48.13 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892032
 protein coding gene Chr2:80242314-80277969 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025884
 protein coding gene Chr2:80989565-81029246 (-)
A/J MGP_AJ_G0025861
 protein coding gene Chr2:77871202-77908309 (-)
AKR/J MGP_AKRJ_G0025830
 protein coding gene Chr2:79909677-79947482 (-)
BALB/cJ MGP_BALBcJ_G0025857
 protein coding gene Chr2:78003180-78039013 (-)
C3H/HeJ MGP_C3HHeJ_G0025616
 protein coding gene Chr2:80144512-80182264 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026303
 protein coding gene Chr2:83377173-83416671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023706
 protein coding gene Chr2:75087797-75121293 (-)
CAST/EiJ MGP_CASTEiJ_G0025078
 protein coding gene Chr2:80559540-80613816 (-)
CBA/J MGP_CBAJ_G0025597
 protein coding gene Chr2:86384129-86429023 (-)
DBA/2J MGP_DBA2J_G0025728
 protein coding gene Chr2:77419078-77455020 (-)
FVB/NJ MGP_FVBNJ_G0025690
 protein coding gene Chr2:76766614-76802203 (-)
LP/J MGP_LPJ_G0025816
 protein coding gene Chr2:80857147-80895550 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025721
 protein coding gene Chr2:88260068-88299226 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026359
 protein coding gene Chr2:80071883-80107246 (-)
PWK/PhJ MGP_PWKPhJ_G0024821
 protein coding gene Chr2:77360039-77396233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024627
 protein coding gene Chr2:80296816-80360760 (-)
WSB/EiJ MGP_WSBEiJ_G0025147
 protein coding gene Chr2:80707587-80748139 (-)



Homology
more
  • Human Ortholog
    FRZB, frizzled related protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRZB, frizzled related protein
  • Synonyms
    FRE, FRITZ, FRP-3, FRZB-1, FRZB1, FRZB-PEN, FZRB, hFIZ, OS1, SFRP3, SRFP3
  • Links
    NCBI Gene ID: 2487
    neXtProt AC: NX_Q92765
    UniProt: Q92765

  • Chr Location
    2q32.1; chr2:182833275-182866637 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human FRZB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display defects in motor coordination and capability and a decrease in thermal pain sensation. Mice homozygous for another null allele display enhanced reactive bone formation and cortical bone abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1651
  • Tissues
    472
  • cDNA Data
    47
  • Literature Summary
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20378 NCBI Gene Model | MGI Sequence Detail 35427 C57BL/6J ±  kb
    transcript NM_011356 RefSeq | MGI Sequence Detail 2920 ZRU/MplStud  
    polypeptide P97401 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 4
      cDNA 49
      Primer pair 14
      Other 7

      Microarray probesets 5
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 64
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:343328 Xie Z, et al., ZBTB20 is essential for cochlear maturation and hearing in mice. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2220867120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory