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Spib Gene Detail
Summary
  • Symbol
    Spib
  • Name
    Spi-B transcription factor (Spi-1/PU.1 related)
  • Synonyms
    Spi-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:892986
    NCBI Gene: 272382
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44175417-44181495 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892986
 protein coding gene Chr7:44175417-44181511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032167
 protein coding gene Chr7:44701022-44707103 (-)
A/J MGP_AJ_G0032146
 protein coding gene Chr7:43883170-43889249 (-)
AKR/J MGP_AKRJ_G0032082
 protein coding gene Chr7:45088670-45094765 (-)
BALB/cJ MGP_BALBcJ_G0032158
 protein coding gene Chr7:43879207-43885281 (-)
C3H/HeJ MGP_C3HHeJ_G0031874
 protein coding gene Chr7:45579125-45585211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032650
 protein coding gene Chr7:46960401-46966480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029664
 protein coding gene Chr7:46468422-46474629 (-)
CAST/EiJ MGP_CASTEiJ_G0031202
 protein coding gene Chr7:36958697-36968641 (-)
CBA/J MGP_CBAJ_G0031838
 protein coding gene Chr7:48500428-48508090 (-)
DBA/2J MGP_DBA2J_G0031996
 protein coding gene Chr7:43557228-43563285 (-)
FVB/NJ MGP_FVBNJ_G0031947
 protein coding gene Chr7:43298125-43304201 (-)
LP/J MGP_LPJ_G0032074
 protein coding gene Chr7:45387045-45393122 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031984
 protein coding gene Chr7:47236789-47242879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032666
 protein coding gene Chr7:44308591-44315455 (-)
PWK/PhJ MGP_PWKPhJ_G0030925
 protein coding gene Chr7:36905849-36912099 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030762
 protein coding gene Chr7:32312468-32318563 (-)
WSB/EiJ MGP_WSBEiJ_G0031319
 protein coding gene Chr7:44765725-44771819 (-)



Homology
more
  • Human Ortholog
    SPIB, Spi-B transcription factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPIB, Spi-B transcription factor
  • Synonyms
    SPI-B
  • Links
    NCBI Gene ID: 6689
    neXtProt AC: NX_Q01892
    UniProt: Q01892

  • Chr Location
    19q13.33; chr19:50418938-50431314 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit severe defects in B cell function and selective T cell-dependent humoral immune responses. Mutant B cells display a defective germinal center reaction upon immunization with DNP-KLH and proliferate poorly in vitro in responseto IgM cross-linking.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    100
  • cDNA Data
    18
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008193 Ensembl Gene Model | MGI Sequence Detail 6079 C57BL/6J ±  kb
    transcript ENSMUST00000098483 Ensembl | MGI Sequence Detail 853 Not Applicable  
    polypeptide ENSMUSP00000096084 Ensembl | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 37
    • Earliest
      J:2525 Ray D, et al., Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1. Mol Cell Biol. 1992 Oct;12(10):4297-304
    • Latest
      J:354604 Sasaki T, et al., Food antigens suppress small intestinal tumorigenesis. Front Immunol. 2024;15:1373766
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory