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Scarb1 Gene Detail
Summary
  • Symbol
    Scarb1
  • Name
    scavenger receptor class B, member 1
  • Synonyms
    Cd36l1, Chohd1, Chohd1, Cla-1, D5Ertd460e, Hdlq1, Hlb398, Srb1, SR-BI, SRBI
  • Feature Type
    protein coding gene
  • IDs
    MGI:893578
    NCBI Gene: 20778
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:125354151-125418082 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 64.11 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1689 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_893578
 protein coding gene Chr5:125354151-125418158 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030109
 protein coding gene Chr5:129106127-129180129 (-)
A/J MGP_AJ_G0030074
 protein coding gene Chr5:123708057-123772556 (-)
AKR/J MGP_AKRJ_G0030010
 protein coding gene Chr5:127711452-127777176 (-)
BALB/cJ MGP_BALBcJ_G0030085
 protein coding gene Chr5:125040281-125106846 (-)
C3H/HeJ MGP_C3HHeJ_G0029802
 protein coding gene Chr5:128321707-128388357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030538
 protein coding gene Chr5:134109510-134186252 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027764
 protein coding gene Chr5:118241701-118307201 (-)
CAST/EiJ MGP_CASTEiJ_G0029211
 protein coding gene Chr5:127457214-127530987 (-)
CBA/J MGP_CBAJ_G0029772
 protein coding gene Chr5:139364975-139437175 (-)
DBA/2J MGP_DBA2J_G0029922
 protein coding gene Chr5:123725546-123790506 (-)
FVB/NJ MGP_FVBNJ_G0029878
 protein coding gene Chr5:122796265-122862727 (-)
LP/J MGP_LPJ_G0030011
 protein coding gene Chr5:129623792-129699066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029909
 protein coding gene Chr5:142884467-142954789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030579
 protein coding gene Chr5:127334778-127404338 (-)
PWK/PhJ MGP_PWKPhJ_G0028925
 protein coding gene Chr5:122565364-122631131 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028762
 protein coding gene Chr5:124956674-125033478 (-)
WSB/EiJ MGP_WSBEiJ_G0029285
 protein coding gene Chr5:128031636-128102137 (-)



Homology
more
  • Human Ortholog
    SCARB1, scavenger receptor class B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCARB1, scavenger receptor class B member 1
  • Synonyms
    CD36L1, CLA-1, CLA1, HDLCQ6, HDLQTL6, SRB1, SR-BI
  • Links
    NCBI Gene ID: 949
    neXtProt AC: NX_Q8WTV0
    UniProt: Q8WTV0

  • Chr Location
    12q24.31; chr12:124776856-124882668 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 10 alleles in 12 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    179 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations result in abnormal lipoprotein metablolism and, for one allele, reversible female infertility. An ENU mutant shows increased cholesterol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    960
  • Tissues
    112
  • cDNA Data
    23
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20778 NCBI Gene Model | MGI Sequence Detail 63932 C57BL/6J ±  kb
    transcript NM_001424496 RefSeq | MGI Sequence Detail 2549 C57BL/6  
    polypeptide Q61009 UniProt | EBI | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 23
      Primer pair 7
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1196331, MGI:2140809, MGI:2387134, MGI:3513270, MGI:3575156
    References
    more
    • Summaries
      All 320
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 21
      Phenotypes 179
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353353 Shamsuzzaman S, et al., Novel Mouse Model of Myocardial Infarction, Plaque Rupture, and Stroke Shows Improved Survival With Myeloperoxidase Inhibition. Circulation. 2024 Aug 27;150(9):687-705
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory