Cirbp MGI Mouse Gene Detail - MGI:893588 - cold inducible RNA binding protein

Symbol

Cirbp
Name

cold inducible RNA binding protein
Synonyms

Cirp

Feature Type

protein coding gene
IDs

MGI:893588
NCBI Gene: 12696
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:80001824-80008620 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

161 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893588	protein coding gene	Chr10:80001819-80008620 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017486	protein coding gene	Chr10:80751266-80758462 (+)
A/J	MGP_AJ_G0017464	protein coding gene	Chr10:77928466-77935230 (+)
AKR/J	MGP_AKRJ_G0017425	protein coding gene	Chr10:80056648-80063991 (+)
BALB/cJ	MGP_BALBcJ_G0017426	protein coding gene	Chr10:78151241-78158608 (+)
C3H/HeJ	MGP_C3HHeJ_G0017249	protein coding gene	Chr10:80155017-80161790 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017880	protein coding gene	Chr10:83533827-83541405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015568	protein coding gene	Chr10:74152947-74162841 (+)
CAST/EiJ	MGP_CASTEiJ_G0016816	protein coding gene	Chr10:80359882-80366605 (+)
CBA/J	MGP_CBAJ_G0017221	protein coding gene	Chr10:86773094-86783448 (+)
DBA/2J	MGP_DBA2J_G0017327	protein coding gene	Chr10:77147626-77156610 (+)
FVB/NJ	MGP_FVBNJ_G0017321	protein coding gene	Chr10:76332029-76339640 (+)
LP/J	MGP_LPJ_G0017398	protein coding gene	Chr10:81231296-81238086 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017347	protein coding gene	Chr10:88724056-88731948 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017921	protein coding gene	Chr10:80036467-80044410 (+)
PWK/PhJ	MGP_PWKPhJ_G0016597	protein coding gene	Chr10:77012950-77020117 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016386	protein coding gene	Chr10:79017358-79024077 (+)
WSB/EiJ	MGP_WSBEiJ_G0016876	protein coding gene	Chr10:80073544-80080252 (+)

Human Ortholog

CIRBP, cold inducible RNA binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIRBP, cold inducible RNA binding protein
Synonyms

CIRP
Links

HGNC:1982

NCBI Gene ID: 1153

neXtProt AC: NX_Q14011

UniProt: Q14011
Chr Location

19p13.3; chr19:1259384-1274880 (+) GRCh38

MGI Vertebrate Homology

Cirbp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CIRBP
Gene Tree

Cirbp

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

55
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

49
Targeted

2
Genomic Mutations

1 involving Cirbp
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired spermatogonia proliferation.

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All GO Annotations

30
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

33
cDNA Data

74
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RBM3

Xenbase cirbp

ZFIN cirbpa, cirbpb

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All Sequences

57
RefSeq

13
UniProt

3
CCDS

CCDS35975.1

Ensembl

ENSMUSG00000045193 (Evidence)
NCBI Gene

12696

			Length	Strain/Species	Flank
genomic	12696	NCBI Gene Model \| MGI Sequence Detail	6797	C57BL/6J	± kb
transcript	NM_001379421	RefSeq \| MGI Sequence Detail	1477	ZRU/MplStud
polypeptide	P60824	UniProt \| EBI \| MGI Sequence Detail	172	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005499 cold-inducible RNA-binding protein

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034278 RBM3/CIRBP, RNA recognition motif

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote
GlyGen

P60824 1 site, 1 N-linked glycan (1 site)

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All nucleic 76

cDNA 75

Primer pair 1

Microarray probesets 4

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MGI:2143957

Summaries

All 76

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 30
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:351194 Zhou M, et al., BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance. Front Immunol. 2024;15:1426682

TSS for Cirbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94514	Chr10:80003671-80003674 (+)	1,849 bp
Tssr94515	Chr10:80004003-80004006 (+)	2,181 bp
Tssr94516	Chr10:80005555-80005559 (+)	3,733 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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