Cirbp MGI Mouse Gene Detail - MGI:893588 - cold inducible RNA binding protein

Symbol

Cirbp
Name

cold inducible RNA binding protein
Synonyms

Cirp

Feature Type

protein coding gene
IDs

MGI:893588
NCBI Gene: 12696
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:80001824-80008620 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

161 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_893588	protein coding gene	Chr10:80001819-80008620 (+)
129S1/SvImJ	ENSMUSG00200046161	protein coding gene	Chr10:76625502-76632303 (+)
A/J	ENSMUSG00195040732	protein coding gene	Chr10:77021038-77027840 (+)
AKR/J	ENSMUSG00220045873	protein coding gene	Chr10:76618597-76625398 (+)
BALB/cJ	ENSMUSG00180048719	protein coding gene	Chr10:77031530-77038336 (+)
C3H/HeJ	ENSMUSG00175052232	protein coding gene	Chr10:76902232-76909030 (+)
C57BL/6NJ	ENSMUSG00215048340	protein coding gene	Chr10:76643934-76650738 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015568	protein coding gene	Chr10:74152947-74162841 (+)
CAST/EiJ	ENSTCUG00005049472	protein coding gene	Chr10:76529243-76536025 (+)
CBA/J	ENSMUSG00210038422	protein coding gene	Chr10:76758299-76765098 (+)
DBA/2J	ENSMUSG00185044692	protein coding gene	Chr10:77100682-77107481 (+)
FVB/NJ	ENSMUSG00205043163	protein coding gene	Chr10:76813477-76820276 (+)
JF1/MsJ	ENSUMUG00000041722	protein coding gene	Chr10:78331780-78338799 (+)
LP/J	ENSMUSG00230044180	protein coding gene	Chr10:78870415-78877216 (+)
NOD/ShiLtJ	ENSMUSG00190035585	protein coding gene	Chr10:77014412-77021215 (+)
NZO/HlLtJ	ENSMUSG00225048172	protein coding gene	Chr10:83156782-83163580 (+)
PWK/PhJ	ENSLUMG00010043316	protein coding gene	Chr10:76691667-76698474 (+)
SPRET/EiJ	ENSMSPG00010040253	protein coding gene	Chr10:78311273-78317796 (+)
WSB/EiJ	ENSIUOG00005050955	protein coding gene	Chr10:76718764-76725548 (+)

Human Ortholog

CIRBP, cold inducible RNA binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIRBP, cold inducible RNA binding protein
Synonyms

CIRP
Links

HGNC:1982

NCBI Gene ID: 1153

UniProt: Q14011
Chr Location

19p13.3; chr19:1259384-1274880 (+) GRCh38

MGI Vertebrate Homology

Cirbp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CIRBP
Gene Tree

Cirbp

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

48
Targeted

2
Genomic Mutations

1 involving Cirbp
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired spermatogonia proliferation.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

638
Tissues

34
cDNA Data

74
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RBM3

Xenbase cirbp

ZFIN cirbpa, cirbpb

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All Sequences

58
RefSeq

13
UniProt

3
CCDS

CCDS35975.1

Ensembl

ENSMUSG00000045193 (Evidence)
NCBI Gene

12696

			Length	Strain/Species	Flank
genomic	12696	NCBI Gene Model \| MGI Sequence Detail	6797	C57BL/6J	± kb
transcript	NM_001379421	RefSeq \| MGI Sequence Detail	1477	ZRU/MplStud
polypeptide	P60824	UniProt \| EBI \| MGI Sequence Detail	172	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005499 cold-inducible RNA-binding protein

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034278 RBM3/CIRBP, RNA recognition motif

IPR035979 RNA-binding domain superfamily

IPR050441 RNA-binding motif

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryotic-type
GlyGen

P60824 1 site, 1 N-linked glycan (1 site)

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All nucleic 77

cDNA 75

Primer pair 2

Microarray probesets 4

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MGI:2143957

Summaries

All 88

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 34
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:388311 Wang Z, et al., CIRBP maintains skeletal muscle mitochondrial energy homeostasis via mt-ATP6 to ameliorate sarcopenia. Biochem Biophys Res Commun. 2026 Jun 20;829:154183

TSS for Cirbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94514	Chr10:80003671-80003674 (+)	1,849 bp
Tssr94515	Chr10:80004003-80004006 (+)	2,181 bp
Tssr94516	Chr10:80005555-80005559 (+)	3,733 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24