Prl8a2 MGI Mouse Gene Detail - MGI:894281 - prolactin family 8, subfamily a, member 2

Symbol

Prl8a2
Name

prolactin family 8, subfamily a, member 2
Synonyms

DPRP, Dtprp, D/tPRP, mdPRP

Feature Type

protein coding gene
IDs

MGI:894281
NCBI Gene: 13529
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:27529656-27538199 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 12.41 cM
Mapping Data

8 experiments

SNPs within 2kb

311 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894281	protein coding gene	Chr13:27529656-27538199 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020396	protein coding gene	Chr13:24964506-24975492 (+)
A/J	MGP_AJ_G0020347	protein coding gene	Chr13:24424701-24433029 (+)
AKR/J	MGP_AKRJ_G0020327	protein coding gene	Chr13:24780406-24788835 (+)
BALB/cJ	MGP_BALBcJ_G0020345	protein coding gene	Chr13:24434662-24447296 (+)
C3H/HeJ	MGP_C3HHeJ_G0020148	protein coding gene	Chr13:24842559-24852873 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020782	protein coding gene	Chr13:25846334-25856420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018367	protein coding gene	Chr13:23061982-23070778 (+)
CAST/EiJ	MGP_CASTEiJ_G0019666	protein coding gene	Chr13:24538322-24548965 (+)
CBA/J	MGP_CBAJ_G0020102	protein coding gene	Chr13:26908551-26918991 (+)
DBA/2J	MGP_DBA2J_G0020226	protein coding gene	Chr13:23972989-23985288 (+)
FVB/NJ	MGP_FVBNJ_G0020212	protein coding gene	Chr13:23571054-23581013 (+)
LP/J	MGP_LPJ_G0020302	protein coding gene	Chr13:25233165-25242700 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020240	protein coding gene	Chr13:27188218-27208720 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020822	protein coding gene	Chr13:24620097-24628245 (+)
PWK/PhJ	MGP_PWKPhJ_G0019420	protein coding gene	Chr13:23873429-23882224 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019236	protein coding gene	Chr13:23520633-23528926 (+)
WSB/EiJ	MGP_WSBEiJ_G0019726	protein coding gene	Chr13:24792907-24809743 (+)

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MGI Vertebrate Homology

Prl8a2 stringent orthology
1 mouse;1 rat
Gene Tree

Prl8a2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Prl8a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit reduced pregnancy success when exposed to hypoxic conditions.

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All GO Annotations

11
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

26
cDNA Data

121
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS26396.1, CCDS70440.1

Ensembl

ENSMUSG00000018259 (Evidence)
NCBI Gene

13529

			Length	Strain/Species	Flank
genomic	13529	NCBI Gene Model \| MGI Sequence Detail	8544	C57BL/6J	± kb
transcript	NM_010088	RefSeq \| MGI Sequence Detail	939	ZRU/MplStud
polypeptide	NP_034218	RefSeq \| MGI Sequence Detail	240	ZRU/MplStud

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UniProt

3 Sequences
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR001400 Somatotropin/prolactin

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All nucleic 129

Genomic 1

cDNA 122

Primer pair 5

Other 1

Microarray probesets 4

Summaries

All 59

Developmental Gene Expression 18

Gene Ontology 2

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:337679 Sirohi VK, et al., Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss. iScience. 2023 Jul 21;26(7):107028

TSS for Prl8a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119035	Chr13:27529644-27529662 (+)	-3 bp
Tssr119036	Chr13:27529667-27529668 (+)	12 bp
Tssr119037	Chr13:27529677-27529684 (+)	25 bp
Tssr119038	Chr13:27532855-27532864 (+)	3,204 bp
Tssr119039	Chr13:27532990-27532996 (+)	3,337 bp
Tssr119040	Chr13:27538097-27538103 (+)	8,444 bp
Tssr119041	Chr13:27538109-27538114 (+)	8,456 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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