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Ebf3 Gene Detail
Summary
  • Symbol
    Ebf3
  • Name
    early B cell factor 3
  • Synonyms
    3110018A08Rik, O/E-2, Olf-1/EBF-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894289
    NCBI Gene: 13593
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:136795402-136916174 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 82.26 cM, cytoband F3-F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894289
 protein coding gene Chr7:136795400-136924528 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033138
 protein coding gene Chr7:142120436-142243675 (-)
A/J MGP_AJ_G0033120
 protein coding gene Chr7:138141920-138264713 (-)
AKR/J MGP_AKRJ_G0033052
 protein coding gene Chr7:141854880-141977097 (-)
BALB/cJ MGP_BALBcJ_G0033121
 protein coding gene Chr7:137888860-138010352 (-)
C3H/HeJ MGP_C3HHeJ_G0032835
 protein coding gene Chr7:141698603-141823216 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033632
 protein coding gene Chr7:147443270-147568339 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030605
 protein coding gene Chr7:139338454-139457955 (-)
CAST/EiJ MGP_CASTEiJ_G0032165
 protein coding gene Chr7:133879466-134003534 (-)
CBA/J MGP_CBAJ_G0032808
 protein coding gene Chr7:152399310-152535125 (-)
DBA/2J MGP_DBA2J_G0032960
 protein coding gene Chr7:136132868-136252312 (-)
FVB/NJ MGP_FVBNJ_G0032913
 protein coding gene Chr7:135988212-136110372 (-)
LP/J MGP_LPJ_G0033054
 protein coding gene Chr7:143655289-143781378 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032945
 protein coding gene Chr7:153188460-153311727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033652
 protein coding gene Chr7:140875262-140999161 (-)
PWK/PhJ MGP_PWKPhJ_G0031871
 protein coding gene Chr7:129282730-129403840 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031716
 protein coding gene Chr7:127628504-127756996 (-)
WSB/EiJ MGP_WSBEiJ_G0032276
 protein coding gene Chr7:141760623-141883791 (-)



Homology
more
  • Human Ortholog
    EBF3, EBF transcription factor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EBF3, EBF transcription factor 3
  • Synonyms
    COE3, EBF-3, HADDS, O/E-2, OE-2
  • Links
    NCBI Gene ID: 253738
    neXtProt AC: NX_Q9H4W6
    UniProt: Q9H4W6

  • Chr Location
    10q26.3; chr10:129835233-129973053 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EBF3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die perinatally and exhibit impaired olfactory neuron projection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1443
  • Tissues
    388
  • cDNA Data
    80
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000010476 Ensembl Gene Model | MGI Sequence Detail 120773 C57BL/6J ±  kb
    transcript ENSMUST00000210774 Ensembl | MGI Sequence Detail 2994 Not Applicable  
    polypeptide ENSMUSP00000147829 Ensembl | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 81
      Primer pair 5
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1920365
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 71
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:40480 Wang SS, et al., The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. J Neurosci. 1997 Jun 1;17(11):4149-58
    • Latest
      J:357469 Sivori M, et al., The pelvic organs receive no parasympathetic innervation. Elife. 2024;15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory