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Rap1b Gene Detail
Summary
  • Symbol
    Rap1b
  • Name
    RAS related protein 1b
  • Synonyms
    2810443E11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894315
    NCBI Gene: 215449
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:117650502-117681879 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 66.32 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894315
 protein coding gene Chr10:117649776-117681940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017764
 protein coding gene Chr10:120780715-120813223 (-)
A/J MGP_AJ_G0017739
 protein coding gene Chr10:116040281-116072221 (-)
AKR/J MGP_AKRJ_G0017703
 protein coding gene Chr10:119440409-119471858 (-)
BALB/cJ MGP_BALBcJ_G0017703
 protein coding gene Chr10:116438726-116475118 (-)
C3H/HeJ MGP_C3HHeJ_G0017528
 protein coding gene Chr10:119676416-119707651 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018158
 protein coding gene Chr10:124920971-124953299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015839
 protein coding gene Chr10:110606123-110637972 (-)
CAST/EiJ MGP_CASTEiJ_G0017088
 protein coding gene Chr10:119971657-120003106 (-)
CBA/J MGP_CBAJ_G0017497
 protein coding gene Chr10:129869485-129902701 (-)
DBA/2J MGP_DBA2J_G0017602
 protein coding gene Chr10:115187435-115219361 (-)
FVB/NJ MGP_FVBNJ_G0017596
 protein coding gene Chr10:114150928-114182549 (-)
LP/J MGP_LPJ_G0017675
 protein coding gene Chr10:121317665-121349114 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017626
 protein coding gene Chr10:132689392-132720868 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018198
 protein coding gene Chr10:119513699-119547231 (-)
PWK/PhJ MGP_PWKPhJ_G0016872
 protein coding gene Chr10:115288805-115320658 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016662
 protein coding gene Chr10:118294363-118322495 (-)
WSB/EiJ MGP_WSBEiJ_G0017149
 protein coding gene Chr10:119706501-119737886 (-)



Homology
more
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAP1B, RAP1B, member of RAS oncogene family
  • Synonyms
    K-REV, RAL1B, THC11
  • Links
    NCBI Gene ID: 5908
    neXtProt AC: NX_P61224
    UniProt: P61224

  • Chr Location
    12q15; chr12:68610855-68671901 (+)  GRCh38
  • Human Ortholog
    RAP1BL, RAP1B like (pseudogene)
  • Links
    NCBI Gene ID: 643752
    UniProt: A6NIZ1

  • Chr Location
    5q13.3; chr5:76173091-76174354 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RAP1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display partial embryonic and perinatal lethality, abdominal, cranial, and hepatic bleeding in mice that die in utero, reduced platelet aggregation, and decreased thrombus formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    12
  • cDNA Data
    32
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215449 NCBI Gene Model | MGI Sequence Detail 31378 C57BL/6J ±  kb
    transcript NM_024457 RefSeq | MGI Sequence Detail 1937 Not Specified  
    polypeptide Q99JI6 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 32
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919983
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 55
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:355712 Yamamoto K, et al., Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. FASEB J. 2023 Dec;37(12):e23310
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory