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Hlcs Gene Detail
Summary
  • Symbol
    Hlcs
  • Name
    holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
  • Synonyms
    410I21.SP6, D16Jhu34
  • Feature Type
    protein coding gene
  • IDs
    MGI:894646
    NCBI Gene: 110948
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93929741-94114430 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.12 cM, cytoband C4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    954 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894646
 protein coding gene Chr16:93929741-94116098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023068
 protein coding gene Chr16:95351650-95522701 (-)
A/J MGP_AJ_G0023036
 protein coding gene Chr16:90875102-91025699 (-)
AKR/J MGP_AKRJ_G0023006
 protein coding gene Chr16:93660852-93819742 (-)
BALB/cJ MGP_BALBcJ_G0023038
 protein coding gene Chr16:91405664-91559636 (-)
C3H/HeJ MGP_C3HHeJ_G0022799
 protein coding gene Chr16:94170638-94335843 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023485
 protein coding gene Chr16:98381443-98544540 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020987
 protein coding gene Chr16:88730779-88888422 (-)
CAST/EiJ MGP_CASTEiJ_G0022318
 protein coding gene Chr16:94918920-95101211 (-)
CBA/J MGP_CBAJ_G0022768
 protein coding gene Chr16:102646266-102830010 (-)
DBA/2J MGP_DBA2J_G0022902
 protein coding gene Chr16:90766180-90918488 (-)
FVB/NJ MGP_FVBNJ_G0022876
 protein coding gene Chr16:89927191-90084848 (-)
LP/J MGP_LPJ_G0022972
 protein coding gene Chr16:95017706-95190977 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022897
 protein coding gene Chr16:107003625-107170752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023503
 protein coding gene Chr16:94173703-94330544 (-)
PWK/PhJ MGP_PWKPhJ_G0022063
 protein coding gene Chr16:91029214-91184923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021893
 protein coding gene Chr16:93713623-93909306 (-)
WSB/EiJ MGP_WSBEiJ_G0022369
 protein coding gene Chr16:94427307-94594419 (-)



Homology
more
  • Human Ortholog
    HLCS, holocarboxylase synthetase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLCS, holocarboxylase synthetase
  • Synonyms
    HCS
  • Links
    NCBI Gene ID: 3141
    neXtProt AC: NX_P50747
    UniProt: P50747

  • Chr Location
    21q22.13; chr21:36748625-36990236 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HLCS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    1 images
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    875
  • Tissues
    141
  • cDNA Data
    30
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040820 Ensembl Gene Model | MGI Sequence Detail 184690 C57BL/6J ±  kb
    transcript ENSMUST00000227141 Ensembl | MGI Sequence Detail 4021 Not Applicable  
    polypeptide ENSMUSP00000153773 Ensembl | MGI Sequence Detail 869 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 7
      cDNA 31
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1338005
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 4
      Diseases 6
      Gene Ontology 8
      Phenotypes 100
    • Earliest
      J:8616 Rajavashisth TB, et al., Cloning and tissue-specific expression of mouse macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci U S A. 1987 Mar;84(5):1157-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory