Serpinb9b MGI Mouse Gene Detail - MGI:894668 - serine (or cysteine) peptidase inhibitor, clade B, member 9b

Symbol

Serpinb9b
Name

serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms

1600019A21Rik, ovalbumin, R86, Spi10, SPI-CI

Feature Type

protein coding gene
IDs

MGI:894668
NCBI Gene: 20706
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr13:33211397-33224571 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.79 cM
Mapping Data

2 experiments

SNPs within 2kb

447 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894668	protein coding gene	Chr13:33211397-33225867 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020432	protein coding gene	Chr13:31041596-31063692 (+)
A/J	MGP_AJ_G0020387	protein coding gene	Chr13:30180748-30195215 (+)
AKR/J	MGP_AKRJ_G0020364	protein coding gene	Chr13:30843022-30856509 (+)
BALB/cJ	MGP_BALBcJ_G0020382	protein coding gene	Chr13:30264517-30278645 (+)
C3H/HeJ	MGP_C3HHeJ_G0020185	protein coding gene	Chr13:30834413-30849465 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020818	protein coding gene	Chr13:32057643-32075545 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0019702	protein coding gene	Chr13:30559042-30573500 (+)
CBA/J	MGP_CBAJ_G0020141	protein coding gene	Chr13:33468518-33488463 (+)
DBA/2J	MGP_DBA2J_G0020263	protein coding gene	Chr13:29690762-29704775 (+)
FVB/NJ	MGP_FVBNJ_G0020248	protein coding gene	Chr13:29314859-29332435 (+)
LP/J	MGP_LPJ_G0020340	protein coding gene	Chr13:31252162-31272586 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020274	protein coding gene	Chr13:33551750-33568026 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020859	protein coding gene	Chr13:30525100-30544601 (+)
PWK/PhJ	MGP_PWKPhJ_G0019457	protein coding gene	Chr13:29888361-29902926 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019278	protein coding gene	Chr13:29404456-29445560 (+)
WSB/EiJ	MGP_WSBEiJ_G0019764	protein coding gene	Chr13:30839452-30854516 (+)

Human Ortholog

SERPINB9, serpin family B member 9

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB9, serpin family B member 9
Synonyms

CAP-3, CAP3, PI-9, PI9
Links

HGNC:8955

NCBI Gene ID: 5272

neXtProt AC: NX_P50453

UniProt: P50453
Chr Location

6p25.2; chr6:2887270-2903309 (-) GRCh38

MGI Vertebrate Homology

Serpinb9b stringent orthology
1 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: SERPINB9
Gene Tree

Serpinb9b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Serpinb9b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a knock-out allele show reduced leukemia susceptibility following murine leukemia virus infection in specific-pathogen free conditions.

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All GO Annotations

19
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

6
cDNA Data

41
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

3
CCDS

CCDS26432.1

Ensembl

ENSMUSG00000021403 (Evidence)
NCBI Gene

20706

			Length	Strain/Species	Flank
genomic	20706	NCBI Gene Model \| MGI Sequence Detail	13175	C57BL/6J	± kb
transcript	NM_011452	RefSeq \| MGI Sequence Detail	1959	ZRU/MplStud
polypeptide	NP_035582	RefSeq \| MGI Sequence Detail	377	ZRU/MplStud

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UniProt

3 Sequences
InterPro Domains

IPR000240 Serpin B9/maspin

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 46

Genomic 2

cDNA 41

Primer pair 2

Other 1

Microarray probesets 2

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MGI:1919261

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 14
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Serpinb9b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119177	Chr13:33211391-33211402 (+)	0 bp
Tssr119178	Chr13:33211485-33211496 (+)	94 bp
Tssr119179	Chr13:33211515-33211530 (+)	126 bp
Tssr119180	Chr13:33223811-33223825 (+)	12,421 bp
Tssr119181	Chr13:33223881-33223900 (+)	12,494 bp
Tssr119182	Chr13:33223928-33223937 (+)	12,536 bp
Tssr119183	Chr13:33223954-33223988 (+)	12,574 bp
Tssr119184	Chr13:33224039-33224057 (+)	12,651 bp
Tssr119185	Chr13:33224243-33224280 (+)	12,865 bp
Tssr119186	Chr13:33224344-33224354 (+)	12,952 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24