Bach1 MGI Mouse Gene Detail - MGI:894680 - BTB and CNC homology 1, basic leucine zipper transcription factor 1

Symbol

Bach1
Name

BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms

6230421P05Rik

Feature Type

protein coding gene
IDs

MGI:894680
NCBI Gene: 12013
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr16:87495842-87530234 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 49.84 cM
Mapping Data

2 experiments

SNPs within 2kb

1281 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894680	protein coding gene	Chr16:87495833-87530234 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022981	protein coding gene	Chr16:88441251-88477032 (+)
A/J	MGP_AJ_G0022949	protein coding gene	Chr16:84355167-84390753 (+)
AKR/J	MGP_AKRJ_G0022919	protein coding gene	Chr16:86921802-86956249 (+)
BALB/cJ	MGP_BALBcJ_G0022951	protein coding gene	Chr16:84887105-84922213 (+)
C3H/HeJ	MGP_C3HHeJ_G0022713	protein coding gene	Chr16:87493202-87527390 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023398	protein coding gene	Chr16:91300378-91343449 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020902	protein coding gene	Chr16:82206267-82240667 (+)
CAST/EiJ	MGP_CASTEiJ_G0022235	protein coding gene	Chr16:87873475-87913995 (+)
CBA/J	MGP_CBAJ_G0022682	protein coding gene	Chr16:95216852-95254477 (+)
DBA/2J	MGP_DBA2J_G0022816	protein coding gene	Chr16:84279969-84314491 (+)
FVB/NJ	MGP_FVBNJ_G0022791	protein coding gene	Chr16:83385853-83419881 (+)
LP/J	MGP_LPJ_G0022885	protein coding gene	Chr16:88121770-88159037 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022810	protein coding gene	Chr16:99773263-99810678 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023416	protein coding gene	Chr16:87400419-87436201 (+)
PWK/PhJ	MGP_PWKPhJ_G0021978	protein coding gene	Chr16:84400448-84434286 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021808	protein coding gene	Chr16:86938627-86972359 (+)
WSB/EiJ	MGP_WSBEiJ_G0022283	protein coding gene	Chr16:87626554-87667317 (+)

Human Ortholog

BACH1, BTB domain and CNC homolog 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BACH1, BTB domain and CNC homolog 1
Synonyms

BACH-1, BTBD24
Links

HGNC:935

NCBI Gene ID: 571

neXtProt AC: NX_O14867

UniProt: O14867
Chr Location

21q21.3; chr21:29194071-29630751 (+) GRCh38

MGI Vertebrate Homology

Bach1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BACH1
Gene Tree

Bach1

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
47 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Endonuclease-mediated

7
Gene trapped

36
Targeted

8
Genomic Mutations

3 involving Bach1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

88 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are healthy and fertile with no gross abnormalities but express elevated levels of HMOX1.

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All GO Annotations

26
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1018
Tissues

254
cDNA Data

69
Literature Summary

17

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BACH1

Xenbase bach1

ZFIN bach1a, bach1b

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All Sequences

46
RefSeq

6
UniProt

4
CCDS

CCDS28293.1

Ensembl

ENSMUSG00000025612 (Evidence)
NCBI Gene

12013

			Length	Strain/Species	Flank
genomic	12013	NCBI Gene Model \| MGI Sequence Detail	34393	C57BL/6J	± kb
transcript	NM_007520	RefSeq \| MGI Sequence Detail	5858	C57BL/6
polypeptide	P97302	UniProt \| EBI \| MGI Sequence Detail	739	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004617 transcription regulator protein BACH1

(term hierarchy)
PDB

2Z8H
InterPro Domains

IPR043321 BACH, basic leucine zipper (bZIP) domain

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR046347 Basic-leucine zipper domain superfamily

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily

IPR050457 Zinc finger and BTB domain-containing

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All nucleic 73

cDNA 69

Primer pair 3

Other 1

Microarray probesets 5

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MGI:1923386, MGI:2146411

Summaries

All 106

Developmental Gene Expression 17

Gene Ontology 7

Phenotypes 47
Earliest

J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bach1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139228	Chr16:87495792-87495847 (+)	-22 bp
Tssr139229	Chr16:87495849-87495872 (+)	19 bp
Tssr139230	Chr16:87495880-87495922 (+)	59 bp
Tssr139231	Chr16:87495942-87495946 (+)	102 bp
Tssr139232	Chr16:87497043-87497056 (+)	1,208 bp
Tssr139233	Chr16:87497088-87497101 (+)	1,253 bp
Tssr139234	Chr16:87516003-87516052 (+)	20,186 bp
Tssr139235	Chr16:87517788-87517793 (+)	21,949 bp
Tssr139236	Chr16:87525959-87525972 (+)	30,124 bp
Tssr139237	Chr16:87526625-87526647 (+)	30,794 bp
Tssr139238	Chr16:87528409-87528413 (+)	32,569 bp
Tssr139239	Chr16:87529540-87529546 (+)	33,701 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24