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Serpinb6b Gene Detail
Summary
  • Symbol
    Serpinb6b
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6b
  • Synonyms
    NK13, ovalbumin, Spi12
  • Feature Type
    protein coding gene
  • IDs
    MGI:894688
    NCBI Gene: 20708
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:33149192-33163050 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 13.78 cM, cytoband A4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894688
 protein coding gene Chr13:33140797-33163050 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020430
 protein coding gene Chr13:30969948-30983806 (+)
A/J MGP_AJ_G0020385
 protein coding gene Chr13:30118441-30132299 (+)
AKR/J MGP_AKRJ_G0020362
 protein coding gene Chr13:30780947-30794805 (+)
BALB/cJ MGP_BALBcJ_G0020380
 protein coding gene Chr13:30200950-30214808 (+)
C3H/HeJ MGP_C3HHeJ_G0020183
 protein coding gene Chr13:30771062-30784920 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020816
 protein coding gene Chr13:31994561-32008419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018407
 protein coding gene Chr13:28436010-28452193 (+)
CAST/EiJ MGP_CASTEiJ_G0019700
 protein coding gene Chr13:30492394-30506242 (+)
CBA/J MGP_CBAJ_G0020139
 protein coding gene Chr13:33400079-33413937 (+)
DBA/2J MGP_DBA2J_G0020261
 protein coding gene Chr13:29627744-29641602 (+)
FVB/NJ MGP_FVBNJ_G0020246
 protein coding gene Chr13:29251696-29265554 (+)
LP/J MGP_LPJ_G0020338
 protein coding gene Chr13:31187681-31201539 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020272
 protein coding gene Chr13:33484522-33498380 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020857
 protein coding gene Chr13:30455386-30469244 (+)
PWK/PhJ MGP_PWKPhJ_G0019455
 protein coding gene Chr13:29820101-29835502 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019276
 protein coding gene Chr13:29369967-29385048 (+)
WSB/EiJ MGP_WSBEiJ_G0019762
 protein coding gene Chr13:30769742-30783592 (+)



Homology
more
  • Human Ortholog
    SERPINB6, serpin family B member 6
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB6, serpin family B member 6
  • Synonyms
    CAP, DFNB91, MSTP057, PI-6, PI6, PTI, SPI3
  • Links
    NCBI Gene ID: 5269
    neXtProt AC: NX_P35237
    UniProt: P35237

  • Chr Location
    6p25.2; chr6:2948159-2972165 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SERPINB6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    23
  • cDNA Data
    40
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042842 Ensembl Gene Model | MGI Sequence Detail 13859 C57BL/6J ±  kb
transcript ENSMUST00000110293 Ensembl | MGI Sequence Detail 2193 Not Applicable  
polypeptide ENSMUSP00000105922 Ensembl | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 2
    cDNA 40
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:305733 Yu HF, et al., Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization. J Cell Mol Med. 2020 Jun;24(12):7023-7033
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory