Unc5b MGI Mouse Gene Detail - MGI:894703

Symbol

Unc5b
Name

unc-5 netrin receptor B
Synonyms

6330415E02Rik, D10Bwg0792e, Unc5h2

Feature Type

protein coding gene
IDs

MGI:894703
NCBI Gene: 107449
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:60598373-60667360 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 31.52 cM, cytoband B4
Mapping Data

4 experiments

SNPs within 2kb

1775 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_894703	protein coding gene	Chr10:60598372-60667360 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017272	protein coding gene	Chr10:60024274-60100113 (-)
A/J	MGP_AJ_G0017250	protein coding gene	Chr10:58253246-58324945 (-)
AKR/J	MGP_AKRJ_G0017210	protein coding gene	Chr10:59775496-59844154 (-)
BALB/cJ	MGP_BALBcJ_G0017210	protein coding gene	Chr10:58332982-58405584 (-)
C3H/HeJ	MGP_C3HHeJ_G0017033	protein coding gene	Chr10:59677024-59750835 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017668	protein coding gene	Chr10:62163260-62235829 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015359	protein coding gene	Chr10:55235347-55304558 (-)
CAST/EiJ	MGP_CASTEiJ_G0016604	protein coding gene	Chr10:59651277-59728497 (-)
CBA/J	MGP_CBAJ_G0017005	protein coding gene	Chr10:64451293-64526693 (-)
DBA/2J	MGP_DBA2J_G0017110	protein coding gene	Chr10:57542656-57613619 (-)
FVB/NJ	MGP_FVBNJ_G0017104	protein coding gene	Chr10:56788715-56867197 (-)
LP/J	MGP_LPJ_G0017185	protein coding gene	Chr10:60436409-60511732 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017132	protein coding gene	Chr10:66858223-66932384 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017706	protein coding gene	Chr10:59574224-59649336 (-)
PWK/PhJ	MGP_PWKPhJ_G0016387	protein coding gene	Chr10:57364902-57436632 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016170	protein coding gene	Chr10:58911867-58982252 (-)
WSB/EiJ	MGP_WSBEiJ_G0016668	protein coding gene	Chr10:59501943-59576125 (-)

Human Ortholog

UNC5B, unc-5 netrin receptor B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC5B, unc-5 netrin receptor B
Synonyms

p53RDL1, UNC5H2
Links

HGNC:12568

NCBI Gene ID: 219699

neXtProt AC: NX_Q8IZJ1

UniProt: Q8IZJ1
Chr Location

10q22.1; chr10:71212570-71302864 (+) GRCh38

MGI Vertebrate Homology

Unc5b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UNC5B
Gene Tree

Unc5b

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

7
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Unc5b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a severely hypomorphic allele exhibit background sensitive lethality during organogenesis.

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All GO Annotations

22
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1217
Tissues

189
cDNA Data

54
Literature Summary

46

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase unc5b

ZFIN unc5b

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All Sequences

54
RefSeq

4
UniProt

4
CCDS

CCDS23872.1, CCDS88011.1

Ensembl

ENSMUSG00000020099 (Evidence)
NCBI Gene

107449

			Length	Strain/Species	Flank
genomic	107449	NCBI Gene Model \| MGI Sequence Detail	68988	C57BL/6J	± kb
transcript	NM_029770	RefSeq \| MGI Sequence Detail	5884	ZRU/MplStud
polypeptide	Q8K1S3	UniProt \| EBI \| MGI Sequence Detail	945	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017094 netrin receptor UNC5B

(term hierarchy)
PDB

1WMG, 6OOL
InterPro Domains

IPR052065 Complement and asymmetry regulator

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR037936 Netrin receptor UNC5

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR042156 UNC5B, death domain

IPR033772 UPA domain

IPR000906 ZU5 domain
GlyGen

Q8K1S3 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 63

cDNA 54

Primer pair 7

Other 2

Microarray probesets 5

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MGD-MRK-34085, MGI:106392, MGI:1924103

Summaries

All 119

Developmental Gene Expression 46

Gene Ontology 12

Phenotypes 32
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:358788 Zhao R, et al., Axo-axonic synaptic input drives homeostatic plasticity by tuning the axon initial segment structurally and functionally. Sci Adv. 2024 Aug 2;10(31):eadk4331

TSS for Unc5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97739	Chr10:60667382-60667396 (-)	-29 bp
Tssr97738	Chr10:60667350-60667367 (-)	1 bp
Tssr97737	Chr10:60667270-60667288 (-)	81 bp
Tssr97736	Chr10:60667231-60667251 (-)	119 bp
Tssr97735	Chr10:60667213-60667225 (-)	141 bp
Tssr97734	Chr10:60652750-60652768 (-)	14,601 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24