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Vars1 Gene Detail
Summary
  • Symbol
    Vars1
  • Name
    valyl-tRNA synthetase 1
  • Synonyms
    Bat-6, Bat6, D17H6S56E, G7a, Vars, Vars2
  • Feature Type
    protein coding gene
  • IDs
    MGI:90675
    NCBI Gene: 22321
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35219963-35235298 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.54 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_90675
 protein coding gene Chr17:35219895-35235304 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023605
 protein coding gene Chr17:35133522-35148803 (+)
A/J MGP_AJ_G0023565
 protein coding gene Chr17:33975342-33990566 (+)
AKR/J MGP_AKRJ_G0023533
 protein coding gene Chr17:34444588-34459881 (+)
BALB/cJ MGP_BALBcJ_G0023571
 protein coding gene Chr17:34104716-34120614 (+)
C3H/HeJ MGP_C3HHeJ_G0023332
 protein coding gene Chr17:34839279-34855287 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024010
 protein coding gene Chr17:36474773-36490068 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021491
 protein coding gene Chr17:31742685-31756905 (+)
CAST/EiJ MGP_CASTEiJ_G0022829
 protein coding gene Chr17:34843370-34858662 (+)
CBA/J MGP_CBAJ_G0023310
 protein coding gene Chr17:37984457-38009882 (+)
DBA/2J MGP_DBA2J_G0023438
 protein coding gene Chr17:33293433-33308725 (+)
FVB/NJ MGP_FVBNJ_G0023405
 protein coding gene Chr17:33129092-33144998 (+)
LP/J MGP_LPJ_G0023515
 protein coding gene Chr17:35461362-35476654 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023427
 protein coding gene Chr17:36915912-36931054 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024055
 protein coding gene Chr17:34668157-34684097 (+)
PWK/PhJ MGP_PWKPhJ_G0022576
 protein coding gene Chr17:32124545-32140262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022396
 protein coding gene Chr17:32678566-32693848 (+)
WSB/EiJ MGP_WSBEiJ_G0022892
 protein coding gene Chr17:34781925-34797046 (+)



Homology
more
  • Human Ortholog
    VARS1, valyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VARS1, valyl-tRNA synthetase 1
  • Synonyms
    G7A, NDMSCA, VARS, VARS2
  • Links
    NCBI Gene ID: 7407
    neXtProt AC: NX_P26640
    UniProt: P26640

  • Chr Location
    6p21.33; chr6:31777518-31795752 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    243
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007029 Ensembl Gene Model | MGI Sequence Detail 15336 C57BL/6J ±  kb
transcript ENSMUST00000173584 Ensembl | MGI Sequence Detail 4048 Not Applicable  
polypeptide ENSMUSP00000133994 Ensembl | MGI Sequence Detail 1278 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000017258 valine--tRNA ligase
    (term hierarchy)
  • EC
    6.1.1.9
  • InterPro Domains
    IPR002300 Aminoacyl-tRNA synthetase, class Ia
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR050802 Elongation Factors and Glutathione S-transferases
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR002303 Valine-tRNA ligase
    IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
    IPR033705 Valyl tRNA synthetase, anticodon-binding domain
    IPR037118 Valyl-tRNA synthetase, tRNA-binding arm superfamily
  • GlyGen
    Q9Z1Q9 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 260
    Genomic 15
    cDNA 245

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-1503, MGD-MRK-1511, MGD-MRK-4482, MGI:7482304
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:1314 Lafuse WP, et al., PFGE mapping and RFLP analysis of the S/D region of the mouse H-2 complex. Immunogenetics. 1992;36(2):110-6
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory