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Serp1 Gene Detail
Summary
  • Symbol
    Serp1
  • Name
    stress-associated endoplasmic reticulum protein 1
  • Synonyms
    D3Ucla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:92638
    NCBI Gene: 28146
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:58429390-58433305 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 28.58 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_92638
 protein coding gene Chr3:58427238-58433313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027235
 protein coding gene Chr3:57360949-57367024 (-)
A/J MGP_AJ_G0027195
 protein coding gene Chr3:55577629-55583705 (-)
AKR/J MGP_AKRJ_G0027165
 protein coding gene Chr3:56718586-56724666 (-)
BALB/cJ MGP_BALBcJ_G0027208
 protein coding gene Chr3:55388221-55394302 (-)
C3H/HeJ MGP_C3HHeJ_G0026951
 protein coding gene Chr3:56939774-56945855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027654
 protein coding gene Chr3:59470979-59477054 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025008
 protein coding gene Chr3:51919526-51925762 (-)
CAST/EiJ MGP_CASTEiJ_G0026403
 protein coding gene Chr3:57101836-57107906 (-)
CBA/J MGP_CBAJ_G0026927
 protein coding gene Chr3:61440020-61446101 (-)
DBA/2J MGP_DBA2J_G0027061
 protein coding gene Chr3:55072546-55078627 (-)
FVB/NJ MGP_FVBNJ_G0027029
 protein coding gene Chr3:54044310-54050385 (-)
LP/J MGP_LPJ_G0027173
 protein coding gene Chr3:58104517-58110592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027047
 protein coding gene Chr3:65580568-65586648 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027712
 protein coding gene Chr3:56671777-56677852 (-)
PWK/PhJ MGP_PWKPhJ_G0026135
 protein coding gene Chr3:54718758-54724826 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025948
 protein coding gene Chr3:56345861-56351945 (-)
WSB/EiJ MGP_WSBEiJ_G0026477
 protein coding gene Chr3:56751317-56757400 (-)



Homology
more
  • Human Ortholog
    SERP1, stress associated endoplasmic reticulum protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERP1, stress associated endoplasmic reticulum protein 1
  • Synonyms
    RAMP4
  • Links
    NCBI Gene ID: 27230
    neXtProt AC: NX_Q9Y6X1
    UniProt: Q9Y6X1

  • Chr Location
    3q25.1; chr3:150541998-150603228 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutation results in postnatal growth retardation, decreased viablilty, impaired glucose tolerance, impaired growth hormone secretion and reduced size of some exocrine glands as well as exocrine gland target tissues
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    7
  • cDNA Data
    407
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 28146 NCBI Gene Model | MGI Sequence Detail 3916 C57BL/6J ±  kb
    transcript NM_030685 RefSeq | MGI Sequence Detail 2457 ZRU/MplStud  
    polypeptide Q9Z1W5 UniProt | EBI | MGI Sequence Detail 66 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014676 stress-associated endoplasmic reticulum protein 1
      (term hierarchy)
    • InterPro Domains
      IPR010580 Stress-associated endoplasmic reticulum protein
    Molecular
    Reagents
    less
    • All nucleic 409
      cDNA 407
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-6517
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory