Dbi MGI Mouse Gene Detail - MGI:94865 - diazepam binding inhibitor

Symbol

Dbi
Name

diazepam binding inhibitor
Synonyms

Acbp, diazepam-binding inhibitor, endozepine, EP

Feature Type

protein coding gene
IDs

MGI:94865
NCBI Gene: 13167
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:120041010-120048808 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.65 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94865	protein coding gene	Chr1:120041010-120048826 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016403	protein coding gene	Chr1:122896248-122903968 (-)
A/J	MGP_AJ_G0016386	protein coding gene	Chr1:118491029-118498749 (-)
AKR/J	MGP_AKRJ_G0016351	protein coding gene	Chr1:121990540-121998260 (-)
BALB/cJ	MGP_BALBcJ_G0016346	protein coding gene	Chr1:118753539-118761271 (-)
C3H/HeJ	MGP_C3HHeJ_G0016172	protein coding gene	Chr1:122147857-122155577 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016807	protein coding gene	Chr1:127579347-127587085 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014520	protein coding gene	Chr1:112135626-112145262 (-)
CAST/EiJ	MGP_CASTEiJ_G0015753	protein coding gene	Chr1:120942465-120950250 (-)
CBA/J	MGP_CBAJ_G0016145	protein coding gene	Chr1:132003499-132011219 (-)
DBA/2J	MGP_DBA2J_G0016251	protein coding gene	Chr1:117513546-117521274 (-)
FVB/NJ	MGP_FVBNJ_G0016250	protein coding gene	Chr1:116266495-116274215 (-)
LP/J	MGP_LPJ_G0016322	protein coding gene	Chr1:124244955-124252675 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016275	protein coding gene	Chr1:137747609-137755341 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016843	protein coding gene	Chr1:121703772-121711504 (-)
PWK/PhJ	MGP_PWKPhJ_G0015539	protein coding gene	Chr1:116492513-116500347 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015327	protein coding gene	Chr1:120587530-120596575 (-)
WSB/EiJ	MGP_WSBEiJ_G0015815	protein coding gene	Chr1:121579874-121587631 (-)

Human Ortholog

DBI, diazepam binding inhibitor, acyl-CoA binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DBI, diazepam binding inhibitor, acyl-CoA binding protein
Synonyms

ACBD1, ACBP, CCK-RP, EP
Links

HGNC:2690

NCBI Gene ID: 1622

neXtProt AC: NX_P07108

UniProt: P07108
Chr Location

2q14.2; chr2:119366924-119372550 (+) GRCh38

MGI Vertebrate Homology

Dbi stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DBI
Gene Tree

Dbi

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References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 4 alleles in 5 genetic backgrounds
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

7
Radiation induced

1
Spontaneous

1
Targeted

7
Genomic Mutations

4 involving Dbi
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal fur and skin morphology at P16 and impaired metabolic changes at weaning with reduced growth and hepatic cholesterol synthesis. Mice homozygous for a different knock-out allele complete exhibit embryonic lethality around implantation.

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All GO Annotations

34
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

18
cDNA Data

434
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dbi

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All Sequences

61
RefSeq

4
UniProt

6
CCDS

CCDS15230.1, CCDS15231.1

Ensembl

ENSMUSG00000026385 (Evidence)
NCBI Gene

13167

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026385	Ensembl Gene Model \| MGI Sequence Detail	7799	C57BL/6J	± kb
transcript	ENSMUST00000151708	Ensembl \| MGI Sequence Detail	491	Not Applicable
polypeptide	ENSMUSP00000114705	Ensembl \| MGI Sequence Detail	135	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006295 acyl-CoA-binding protein

(term hierarchy)
InterPro Domains

IPR000582 Acyl-CoA-binding protein, ACBP

IPR022408 Acyl-CoA-binding protein, ACBP, conserved site

IPR035984 Acyl-CoA binding protein superfamily

IPR014352 FERM/acyl-CoA-binding protein superfamily
GlyGen

P31786 1 site, 1 O-linked glycan (1 site)

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All nucleic 437

Genomic 1

cDNA 434

Primer pair 2

Microarray probesets 6

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MGD-MRK-36403, MGD-MRK-8802, MGI:107826

Summaries

All 96

Developmental Gene Expression 15

Diseases 1

Gene Ontology 9

Phenotypes 41
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:330826 Doherty R, et al., Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse. Sci Rep. 2022 Oct 14;12(1):17267

TSS for Dbi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13241	Chr1:120048788-120048803 (-)	12 bp
Tssr13240	Chr1:120048760-120048771 (-)	42 bp
Tssr13239	Chr1:120048736-120048753 (-)	63 bp
Tssr13238	Chr1:120047870-120047924 (-)	911 bp
Tssr13237	Chr1:120047783-120047815 (-)	1,009 bp
Tssr13236	Chr1:120044148-120044175 (-)	4,646 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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