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Dcn Gene Detail
Summary
  • Symbol
    Dcn
  • Name
    decorin
  • Synonyms
    DC, SLRR1B
  • Feature Type
    protein coding gene
  • IDs
    MGI:94872
    NCBI Gene: 13179
  • Alliance
    gene page
  • Transcription Start Sites
    39 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:97315471-97354005 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 50.27 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1489 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94872
 protein coding gene Chr10:97315362-97354025 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017675
 protein coding gene Chr10:99201579-99250408 (+)
A/J MGP_AJ_G0017654
 protein coding gene Chr10:95650740-95689163 (+)
AKR/J MGP_AKRJ_G0017614
 protein coding gene Chr10:98376180-98414471 (+)
BALB/cJ MGP_BALBcJ_G0017618
 protein coding gene Chr10:95949338-95989024 (+)
C3H/HeJ MGP_C3HHeJ_G0017441
 protein coding gene Chr10:98400358-98440180 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018074
 protein coding gene Chr10:102641749-102682155 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015756
 protein coding gene Chr10:91169135-91209265 (+)
CAST/EiJ MGP_CASTEiJ_G0017004
 protein coding gene Chr10:98468099-98508649 (+)
CBA/J MGP_CBAJ_G0017410
 protein coding gene Chr10:106667379-106710526 (+)
DBA/2J MGP_DBA2J_G0017516
 protein coding gene Chr10:94715545-94754529 (+)
FVB/NJ MGP_FVBNJ_G0017509
 protein coding gene Chr10:93982244-94021169 (+)
LP/J MGP_LPJ_G0017590
 protein coding gene Chr10:99786613-99842215 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017539
 protein coding gene Chr10:107831336-107871994 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018112
 protein coding gene Chr10:98304071-98342578 (+)
PWK/PhJ MGP_PWKPhJ_G0016786
 protein coding gene Chr10:94878226-94917713 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016575
 protein coding gene Chr10:97179979-97221492 (+)
WSB/EiJ MGP_WSBEiJ_G0017064
 protein coding gene Chr10:98311027-98349331 (+)



Homology
more
  • Human Ortholog
    DCN, decorin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DCN, decorin
  • Synonyms
    CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
  • Links
    NCBI Gene ID: 1634
    neXtProt AC: NX_P07585
    UniProt: P07585

  • Chr Location
    12q21.33; chr12:91140484-91183217 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Dcn mouse models; 3 with human DCN associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 8 genetic backgrounds
    26 phenotypes from multigenic genotypes
    4 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice have fragile skin and exhibit abnormal collagen morphology in skin and tendons, supporting this gene's role in regulating collagen fiber formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1203
  • Tissues
    382
  • cDNA Data
    301
  • Literature Summary
    79
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019929 Ensembl Gene Model | MGI Sequence Detail 38535 C57BL/6J ±  kb
    transcript ENSMUST00000105287 Ensembl | MGI Sequence Detail 1758 Not Applicable  
    polypeptide ENSMUSP00000100924 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000000094 decorin
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR003591 Leucine-rich repeat, typical subtype
      IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
      IPR050333 Small Leucine-Rich Proteoglycans
    • GlyGen
      P28654 6 sites, 5 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 322
      Genomic 5
      cDNA 303
      Primer pair 11
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8811
    References
    more
    • Summaries
      All 197
      Developmental Gene Expression 79
      Diseases 4
      Gene Ontology 9
      Phenotypes 64
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:347285 Miladinovic O, et al., A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche. Development. 2024 Apr 1;151(7):dev202614
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory